Journal article

Publication year: 2009

Pages: S146-S146

Journal: Toxicology Letters

Volume number: 189

ISSN: 0378-4274

DOI Link: https://doi.org/10.1016/j.toxlet.2009.06.817

Publisher: Elsevier

Abstract: 

Question: The
retinoid system has a key role in organism development and is highly
sensitive to chemical exposure. Technical PCB-mixtures and individual
PCB congeners modulate the retinoid system at low exposure levels in
subchronic toxicity study, and the present study was performed to extend
the knowledge about retinoid system modulations to include exposure
during early life-stages and follow-up until adult life.

Methods: Female Sprague-Dawley rats (F0) were given 0 or 15 mg/kg/day
Aroclor 1254 p.o. during gestation and lactation and frozen liver and
kidney samples of F1 females at postnatal days (PNDs) 35, 77 and 350,
and F0 dams at PND 30 were analysed for apolar and polar retinoid forms
by HPLC. Serum samples of F1 and F0 females were analysed at PND 77 and
PND 30, respectively.

Results: Aroclor 1254-exposed F1 female rats had significantly increased all-trans-retinoic
acid (RA) concentrations in liver and kidneys (63% and 27%
respectively) at PND 35, whereas hepatic RA concentrations of F1 females
at PND 77 were substantially reduced (−35%). Hepatic 9-cis-4-oxo-13,14-dihydro-retinoic
acid (9C4ODHRA) concentrations were significantly reduced in F1 females
at PNDs 35 and 77. At PNDs 35, 77 and 350, F1 females showed
significantly increased renal retinol (REOH) and reduced hepatic retinyl
palmitate (REPA) concentrations by Aroclor 1254 treatment. F0 females
showed significantly reduced hepatic RA concentrations (−59%), increased
serum RA concentrations (+196%), and reduced hepatic concentrations of
9C4ODHRA, REOH and REPA by Aroclor-1254 treatment.

Conclusion: Perinatal Aroclor 1254 exposure modulates polar and apolar retinoid levels in tissue and life-stage specific manners.

Acknowledgements:
Financial support of Commission of the European Communities (BoneTox,
EU-QLK-CT-2002-02528), Swedish Institute (Sweden), Deutscher
Akademischer Austausch Dienst (A/07/09165, Germany), Generalitat
Valenciana (BEST/2007/082 and BEST/2008/137, Spain), Programa José
Castillejo (JC2007-00107, Ministerio de Educación y Ciencia, Spain), and
Northern Contaminants Program, DIAND, Health Canada (Canada). David
Wahlström and Christina Trossvik for laboratory work.

Harvard Citation style: Esteban, J., Elabbas, L., Giese, N., Bowers, W., Chu, I., Hamscher, G., et al. (2009) Perinatal Aroclor 1254 exposure modulates polar and apolar retinoid levels in tissue and life-stage specific manners, Toxicology Letters, 189, p. S146. https://doi.org/10.1016/j.toxlet.2009.06.817

APA Citation style: Esteban, J., Elabbas, L., Giese, N., Bowers, W., Chu, I., Hamscher, G., & Hakansson, H. (2009). Perinatal Aroclor 1254 exposure modulates polar and apolar retinoid levels in tissue and life-stage specific manners. Toxicology Letters. 189, S146. https://doi.org/10.1016/j.toxlet.2009.06.817