Journal article

Publication year: 2010

Pages: S190-S191

Journal: Toxicology Letters

Volume number: 196

Issue number: Supplement

ISSN: 0378-4274

DOI Link: https://doi.org/10.1016/j.toxlet.2010.03.648

Publisher: Elsevier

Abstract: 
The arctic Inuit population is exposed to persistent organic pollutants, mainly through contaminated fish and seafood, and developing fetuses and breast-fed infants are the most highly exposed population groups.This study investigated the impacts of perinatal exposure to low doses of a chemical mixture (polychlorinated biphenyls, organochlorine pesticides and methylmercury) present in the blood of the arctic Inuit population on the retinoid system and other endpoints, including body and organ weights and enzyme induction, in rat dams and their offspring. Pregnant Sprague–Dawley rats were given the reconstituted mixture (0, 0.05, 0.5 and 5 mg/kg bw/day) from gestational day 1 through weaning. One male and one female offspring were sacrificed at postnatal days (PNDs) 35, 77 and 350 and the dams at 7–10 days after weaning. Frozen samples of liver and kidney were kept for subsequent analyses.Following high dose treatment; hepatic retinoids were decreased in both sexes of the offspring at PNDs 35, 77 and 350, as well as in the dams, while the renal retinoids were increased in both sexes of the offspring but decreased in the dams. Also, body, liver and kidney weights were decreased in the high-dose groups of both sexes of offspring. The effects in the treated offspring were less evident at PND350 than at PNDs 35 and 77, likely due to the discontinued exposure after weaning. Critical effect doses (CEDs) for hepatic retinyl palmitate modulation (5%) ranged between 0.41 and 0.09 mg/kg bw/day at PNDs 35 and 77 respectively; whereas CED for renal retinyl palmitate modulation (5%) at PND 77 was 0.36 mg/kg bw/day. Maximum responses ranged from −21% to −75% for hepatic retinoids. Renal retinyl palmitate showed a maximum response of +97%. CEDs (100%) for hepatic and renal P450 enzyme induction in the offspring at PND35 ranged between 0.42 and 2.87 mg/kg bw/day respectively.

Harvard Citation style: Esteban, J., Elabbas, L., Daniel, B., Giese, N., Hamscher, G., Nau, H., et al. (2010) Effects on the retinoid system and other endpoints in rat offspring and dams following in utero and lactational exposure to a chemical mixture present in the arctic Inuit population, Toxicology Letters, 196(Supplement), pp. S190-S191. https://doi.org/10.1016/j.toxlet.2010.03.648

APA Citation style: Esteban, J., Elabbas, L., Daniel, B., Giese, N., Hamscher, G., Nau, H., Bowers, W., Chu, I., Akesson, A., & Hakansson, H. (2010). Effects on the retinoid system and other endpoints in rat offspring and dams following in utero and lactational exposure to a chemical mixture present in the arctic Inuit population. Toxicology Letters. 196(Supplement), S190-S191. https://doi.org/10.1016/j.toxlet.2010.03.648