Journal article

Publication year: 2009

Pages: S104-S104

Journal: Toxicology Letters

Volume number: 189

Issue number: Supplement

ISSN: 0378-4274

DOI Link: https://doi.org/10.1016/j.toxlet.2009.06.336

Publisher: Elsevier

Abstract: 

PCB180 is a persistent heptachlorinated non-dioxin-like polychlorinated
biphenyl abundantly present in food and the environment. We conducted a
perinatal toxicity study with high purity PCB180 (dioxin-like impurities
2.7 ng TEQ_WHO/g PCB180). Total doses of 0, 10, 30, 100, 300 or 1000 mg/kg were given to pregnant dams in four equal subdoses on gestation days 7–10 by gavage. Litter size was adjusted to 4 males + 4
females on postnatal day (PND)1, pups were weaned on PND28 and samples
taken on PNDs 7, 35 and 84. Maternal bodyweight gain was not
significantly affected, but neonatal mortality was increased at 1000 mg/kg. Offspring liver weights were increased at 100 mg/kg
and above. Aromatase activity of males was dose-dependently but not
significantly increased in the adrenal gland on PND7 and in the liver on
PND35 and 84, but decreased in the testis on PND35 at 300 and 1000 mg/kg.
Aromatase activity was not affected in ovaries.
Catechol-O-methyltransferase activity in female rat liver was slightly
decreased at 1000 mg/kg on PND84. In PND35 samples, dose-dependently
decreased liver retinol and increased kidney retinyl ester levels were
found. Estimated elimination half-life of PCB180 based on adipose tissue
concentrations on PND35 and 84 at 100 mg/kg was 33 and 35 days in male and female offspring, respectively. LOAEL – based on increased liver weight – was 100 mg/kg, which is equivalent with adipose tissue PCB180 concentration of 318 ng/g lipid in dams on PND30, and 154 and 166 ng/g lipid on PND35 in male and female offspring, respectively.

Harvard Citation style: Miettinen, H., Heikkinen, P., Korkalainen, M., Antunes-Fernandes, E., van Duursen, M., Leslie, H., et al. (2009) Effects of perinatal exposure to high purity PCB180 on rat offspring, Toxicology Letters, 189(Supplement), p. S104. https://doi.org/10.1016/j.toxlet.2009.06.336

APA Citation style: Miettinen, H., Heikkinen, P., Korkalainen, M., Antunes-Fernandes, E., van Duursen, M., Leslie, H., Hamscher, G., Andersson, P., Halldin, K., Hakansson, H., & Viluksela, M. (2009). Effects of perinatal exposure to high purity PCB180 on rat offspring. Toxicology Letters. 189(Supplement), S104. https://doi.org/10.1016/j.toxlet.2009.06.336