Journalartikel

Jahr der Veröffentlichung: 2008

Seiten: 183-189

Zeitschrift: FEMS Immunology and Medical Microbiology

Bandnummer: 53

Heftnummer: 2

ISSN: 0928-8244

eISSN: 1574-695X

DOI Link: https://doi.org/10.1111/j.1574-695X.2008.00408.x

Verlag: Oxford University Press (OUP): Policy B - Oxford Open Option D

Abstract: 
In 2005 and 2006, Francisella tularensis unexpectedly reemerged in western Germany, when several semi-free-living marmosets (Callithrix jacchus) in a research facility died from tularemia and a group of hare hunters became infected. It is believed that hunters may have an elevated risk to be exposed to zoonotic pathogens, including F. tularensis. A previous cross-sectional study of the German population (n=6883) revealed a prevalence of 0.2%. Here, we investigated 286 sera from individuals mainly hunting in districts with emerging tularemia cases (group 1) and 84 sera from a region currently not conspicuous for tularemia (group 2). Methods included standard enzyme-linked immunosorbent assay (ELISA), Western blot analysis and indirect immunofluorescence assay. We found five out of the 286 hunters (1.7%; 95% CI 0.6-4.0%) in group 1 positive with standard ELISA and Western blot, but none in the Berlin area (group 2; 95% CI 0-0.04%). Group 1 showed an elevated risk for hunters to be seropositive for F. tularensis compared with the cross-sectional study (OR=7.7; P < 0.001). This indicates a higher prevalence for tularemia in hunters of a suspected endemic region of Germany.

Harvard-Zitierstil: Jenzora, A., Jansen, A., Ranisch, H., Lierz, M., Wichmann, O. and Grunow, R. (2008) Seroprevalence study of Francisella tularensis among hunters in Germany, FEMS Immunology and Medical Microbiology, 53(2), pp. 183-189. https://doi.org/10.1111/j.1574-695X.2008.00408.x

APA-Zitierstil: Jenzora, A., Jansen, A., Ranisch, H., Lierz, M., Wichmann, O., & Grunow, R. (2008). Seroprevalence study of Francisella tularensis among hunters in Germany. FEMS Immunology and Medical Microbiology. 53(2), 183-189. https://doi.org/10.1111/j.1574-695X.2008.00408.x