Journal article

Publication year: 1997

Pages: 1757-1764

Journal: Liebigs Annalen - recueil

Volume number: 1997

Issue number: 8

ISSN: 0947-3440

DOI Link: https://doi.org/10.1002/jlac.199719970819

Publisher: Wiley-VCH Verlag

Abstract: 
2,4-Dimethylpentane (1) is a typical biconformational backbone segment. When one methyl group in 1 is replaced by a sp(2) bound residue (vinyl, formyl, phenyl), as in compounds 3-6, a small preference for conformer 2b ensues, in which the sp(2) bound group resides in the sterically more hindered position. Oxygen substituents in the 3-position do not change this conformational preference, but in concert with bulkier sp(2)-hybridized groups in the 2-position, a preference for the 2a backbone conformation may be induced, in which the sp(2)-hybridized group is in the less sterically hindered end-of-chain position, cf, compounds 20 and 23.

Harvard Citation style: Göttlich, R., Schopfer, U., Stahl, M. and Hoffmann, R. (1997) Flexible Molecules with Defined Shape, VII. Conformational Analysis of 3,5‐Dimethylhexene Derivatives, Subunits of Polyketide Derived Natural Products, Liebigs Annalen - recueil, 1997(8), pp. 1757-1764. https://doi.org/10.1002/jlac.199719970819

APA Citation style: Göttlich, R., Schopfer, U., Stahl, M., & Hoffmann, R. (1997). Flexible Molecules with Defined Shape, VII. Conformational Analysis of 3,5‐Dimethylhexene Derivatives, Subunits of Polyketide Derived Natural Products. Liebigs Annalen - recueil. 1997(8), 1757-1764. https://doi.org/10.1002/jlac.199719970819