Journal article

Publication year: 2010

Pages: 384-390

Journal: Journal of Veterinary Internal Medicine

Volume number: 24

Issue number: 2

ISSN: 0891-6640

DOI Link: https://doi.org/10.1111/j.1939-1676.2009.0453.x

Publisher: Wiley

Abstract: 
BackgroundThe presence of cytotoxic drug residues in urine of dogs may represent an exposure risk for pet owners and other people as well as a potential environmental contaminant. However, studies on cytotoxic drug residues in excretions of clinical patients are lacking in veterinary oncology.HypothesisVariable concentrations of cytotoxic residues are present in urine samples, depending on sampling time and substance.AnimalsClient-owned dogs with lymphoma or mast cell tumors treated with standard chemotherapy protocols.MethodsUrine samples were collected before, directly after, and on days after administration of chemotherapy. Measurement of vincristine, vinblastine, cyclophosphamide, and doxorubicin residues in canine urine was performed by a quantitative liquid chromatography tandem mass spectrometry (LC/MS/MS) method.ResultsMedian cyclophosphamide residue concentration was 398.2 mu g/L directly after treatment (d0) and was below the level of detection on days 1-3 (d1, d2, d3). Median vincristine residue concentration was 53.8 mu g/L directly after treatment and was 20.2, 11.4, and 6.6 mu g/L on days 1, 2, and 3. Median vinblastine residues were 144.9 (d0), 70.8 (d1), 35.6 (d2), and 18.7 mu g/L (d3) with low concentrations detectable for 7 days after treatment. Median urine doxorubicin concentrations were 354.0 (d0), 165.6 (d1), 156.9 (d2), and 158.2 mu g/L (d3). Low concentrations of doxorubicin were measurable up to 21 days after administration.Conclusions and Clinical ImportanceVariable concentrations of chemotherapeutics were measured in urine samples, depending on sampling time point and drug. Findings may inform current chemoprotection guidelines and help minimize exposure risks.

Harvard Citation style: Knobloch, A., Mohring, S., Eberle, N., Nolte, I., Hamscher, G. and Simon, D. (2010) Cytotoxic Drug Residues in Urine of Dogs Receiving Anticancer Chemotherapy, Journal of Veterinary Internal Medicine, 24(2), pp. 384-390. https://doi.org/10.1111/j.1939-1676.2009.0453.x

APA Citation style: Knobloch, A., Mohring, S., Eberle, N., Nolte, I., Hamscher, G., & Simon, D. (2010). Cytotoxic Drug Residues in Urine of Dogs Receiving Anticancer Chemotherapy. Journal of Veterinary Internal Medicine. 24(2), 384-390. https://doi.org/10.1111/j.1939-1676.2009.0453.x