Journal article

Publication year: 2010

Pages: 379-383

Journal: The Internet Journal of Veterinary Medicine

Volume number: 24

Issue number: 2

ISSN: 0891-6640

DOI Link: https://doi.org/10.1111/j.1939-1676.2009.0469.x

Publisher: Internet Scientific Publications LLC

Abstract: 
BackgroundThe presence of drug residues in blood samples can represent an occupational hazard. However, studies on cytotoxic drug residues in serum of dogs are lacking in veterinary oncology.Objective:To evaluate possible occupational hazards associated with handling of blood samples from dogs receiving oncolytic drugs 7 days after treatment.Animals:Twenty-seven client-owned dogs treated for lymphoma or mast cell tumors with vincristine, vinblastine, cyclophosphamide, or doxorubicin.Methods:Prospective, observational study. Serum samples were either taken 7 days after administration of vincristine, cyclophosphamide, doxorubicin (lymphoma), and vinblastine (mast cell tumor), or 1-2 days after the last concurrent oral administration of cyclophosphamide (mast cell tumor). Additionally, serum was collected within 5 minutes of treatment. Measurement of drug residues in serum was performed by liquid chromatography tandem mass spectrometry (LC/MS/MS).Results:In 33 samples collected within 5 minute of treatment, the median serum concentrations were vincristine: 37 mu g/L (range: 11-87 mu g/L), vinblastine: 13 mu g/L (range: 13-35 mu g/L), cyclophosphamide: 2,484 mu g/L (range: 1,209-2,778 mu g/L), doxorubicin: 404 mu g/L (range: 234-528 mu g/L). In 81 serum samples collected 7 days after treatment vinblastine (7 mu g/L) was detected in 1 sample, and cyclophosphamide (7 and 9 mu g/L) in 2 samples collected 1-2 days after oral administration of cyclophosphamide. Medications were not detected in any of the other samples.Conclusions and Clinical Importance:Handling of blood samples from dogs receiving oncolytic chemotherapy 7 days after treatment with vincristine, vinblastine, cyclophosphamide, and doxorubicin should not present a health hazard.

Harvard Citation style: Knobloch, A., Mohring, S., Eberle, N., Nolte, I., Hamscher, G. and Simon, D. (2010) Drug Residues in Serum of Dogs Receiving Anticancer Chemotherapy, The Internet Journal of Veterinary Medicine, 24(2), pp. 379-383. https://doi.org/10.1111/j.1939-1676.2009.0469.x

APA Citation style: Knobloch, A., Mohring, S., Eberle, N., Nolte, I., Hamscher, G., & Simon, D. (2010). Drug Residues in Serum of Dogs Receiving Anticancer Chemotherapy. The Internet Journal of Veterinary Medicine. 24(2), 379-383. https://doi.org/10.1111/j.1939-1676.2009.0469.x