Journal article

Authors list: Zhang, Yingqi; Yang, Ziran; Yang, Yang; Han, Aiping; Rehneke, Laura; Ding, Liwen; Wei, Yushu; Liu, Zeming; Meng, Yuling; Schaefer, Patrick; Shan, Weixing

Publication year: 2024

Journal: Current Biology

Volume number: 34

Issue number: 13

ISSN: 0960-9822

eISSN: 1879-0445

DOI Link: https://doi.org/10.1016/j.cub.2024.05.064

Publisher: Cell Press

Abstract: 
The root endophytic fungus Serendipita indica establishes beneficial symbioses with a broad spectrum of plants and enhances host resilience against biotic and abiotic stresses. However, little is known about the mechanisms underlying S. indica-mediated plant protection. Here, we report S. indica effector (SIE) 141 and its host target CDSP32, a conserved thioredoxin-like protein, and underlying mechanisms for enhancing pathogen resistance and abiotic salt tolerance in Arabidopsis thaliana . SIE141 binding interfered with canonical targeting of CDSP32 to chloroplasts, leading to its re-location into the plant nucleus. This nuclear translocation is essential for both their interaction and resistance function. Furthermore, SIE141 enhanced oxidoreductase activity of CDSP32, leading to CDSP32-mediated monomerization and activation of NONEXPRESSOR OF PATHOGENESIS-RELATED 1 (NPR1), a key regulator of systemic resistance. Our findings provide functional insights on how S. indica transfers well-known beneficial effects to host plants and indicate CDSP32 as a genetic resource to improve plant resilience to abiotic and biotic stresses.

Harvard Citation style: Zhang, Y., Yang, Z., Yang, Y., Han, A., Rehneke, L., Ding, L., et al. (2024) A symbiont fungal effector relocalizes a plastidic oxidoreductase to nuclei to induce resistance to pathogens and salt stress, Current Biology, 34(13). https://doi.org/10.1016/j.cub.2024.05.064

APA Citation style: Zhang, Y., Yang, Z., Yang, Y., Han, A., Rehneke, L., Ding, L., Wei, Y., Liu, Z., Meng, Y., Schaefer, P., & Shan, W. (2024). A symbiont fungal effector relocalizes a plastidic oxidoreductase to nuclei to induce resistance to pathogens and salt stress. Current Biology. 34(13). https://doi.org/10.1016/j.cub.2024.05.064