Journalartikel

Autorenliste: Singhaarachchi, Pasindu Hansana; Antal, Peter; Calon, Federic; Culmsee, Carsten; Delpech, Jean-Christophe; Feldotto, Martin; Geertsema, Jorine; Hoeksema, Emmy E.; Korosi, Aniko; Laye, Sophie; McQualter, Jonathan; de Rooij, Susanne R.; Rummel, Christoph; Slayo, Mary; Sominsky, Luba; Spencer, Sarah J.

Jahr der Veröffentlichung: 2024

Zeitschrift: Neuroscience & Biobehavioral Reviews

Bandnummer: 162

ISSN: 0149-7634

eISSN: 1873-7528

Open Access Status: Hybrid

DOI Link: https://doi.org/10.1016/j.neubiorev.2024.105724

Verlag: Elsevier

Abstract: 
Alzheimer's disease (AD) is prevalent around the world, yet our understanding of the disease is still very limited. Recent work suggests that the cornerstone of AD may include the inflammation that accompanies it. Failure of a normal pro-inflammatory immune response to resolve may lead to persistent central inflammation that contributes to unsuccessful clearance of amyloid-beta plaques as they form, neuronal death, and ultimately cognitive decline. Individual metabolic, and dietary (lipid) profiles can differentially regulate this inflammatory process with aging, obesity, poor diet, early life stress and other inflammatory factors contributing to a greater risk of developing AD. Here, we integrate evidence for the interface between these factors, and how they contribute to a pro-inflammatory brain milieu. In particular, we discuss the importance of appropriate polyunsaturated fatty acids (PUFA) in the diet for the metabolism of specialised pro-resolving mediators (SPMs); raising the possibility for dietary strategies to improve AD outlook.

Harvard-Zitierstil: Singhaarachchi, P., Antal, P., Calon, F., Culmsee, C., Delpech, J., Feldotto, M., et al. (2024) Aging, sex, metabolic and life experience factors: Contributions to neuro-inflammaging in Alzheimer's disease research, Neuroscience & Biobehavioral Reviews, 162, Article 105724. https://doi.org/10.1016/j.neubiorev.2024.105724

APA-Zitierstil: Singhaarachchi, P., Antal, P., Calon, F., Culmsee, C., Delpech, J., Feldotto, M., Geertsema, J., Hoeksema, E., Korosi, A., Laye, S., McQualter, J., de Rooij, S., Rummel, C., Slayo, M., Sominsky, L., & Spencer, S. (2024). Aging, sex, metabolic and life experience factors: Contributions to neuro-inflammaging in Alzheimer's disease research. Neuroscience & Biobehavioral Reviews. 162, Article 105724. https://doi.org/10.1016/j.neubiorev.2024.105724