Journal article
Authors list: Modafferi, Sergio; Lupo, Gabriella; Tomasello, Mario; Rampulla, Francesco; Ontario, Marialaura; Scuto, Maria; Salinaro, Angela Trovato; Arcidiacono, Antonio; Anfuso, Carmelina Daniela; Legmouz, Maria; Azzaoui, Fatima-Zahra; Palmeri, Agostino; Spano, Sestina; Biamonte, Francesca; Cammilleri, Gaetano; Fritsch, Tilman; Sidenkova, Alena; Calabrese, Edward; Wenzel, Uwe; Calabrese, Vittorio
Publication year: 2024
Pages: 1156-1168
Journal: Current Neuropharmacology
Volume number: 22
Issue number: 7
ISSN: 1570-159X
eISSN: 1875-6190
DOI Link: https://doi.org/10.2174/1570159X21666230817085811
Publisher: Bentham Science Publishers
Abstract:
Autism spectrum disorder (ASD) includes a heterogeneous group of complex neurodevelopmental disorders characterized by atypical behaviors with two core pathological manifestations: deficits in social interaction/communication and repetitive behaviors, which are associated with disturbed redox homeostasis. Modulation of cellular resilience mechanisms induced by low levels of stressors represents a novel approach for the development of therapeutic strategies, and in this context, neuroprotective effects of a wide range of polyphenol compounds have been demonstrated in several in vitro and in vivo studies and thoroughly reviewed. Mushrooms have been used in traditional medicine for many years and have been associated with a long list of therapeutic properties, including antitumor, immunomodulatory, antioxidant, antiviral, antibacterial, and hepatoprotective effects. Our recent studies have strikingly indicated the presence of polyphenols in nutritional mushrooms and demonstrated their protective effects in different models of neurodegenerative disorders in humans and rats. Although their therapeutic effects are exerted through multiple mechanisms, increasing attention is focusing on their capacity to induce endogenous defense systems by modulating cellular signaling processes such as nuclear factor erythroid 2 related factor 2 (Nrf2) and nuclear factor-kappa B (NF-kappa B) pathways. Here we discuss the protective role of hormesis and its modulation by hormetic nutrients in ASD.
Citation Styles
Harvard Citation style: Modafferi, S., Lupo, G., Tomasello, M., Rampulla, F., Ontario, M., Scuto, M., et al. (2024) Antioxidants, Hormetic Nutrition, and Autism, Current Neuropharmacology, 22(7), pp. 1156-1168. https://doi.org/10.2174/1570159X21666230817085811
APA Citation style: Modafferi, S., Lupo, G., Tomasello, M., Rampulla, F., Ontario, M., Scuto, M., Salinaro, A., Arcidiacono, A., Anfuso, C., Legmouz, M., Azzaoui, F., Palmeri, A., Spano, S., Biamonte, F., Cammilleri, G., Fritsch, T., Sidenkova, A., Calabrese, E., Wenzel, U., ...Calabrese, V. (2024). Antioxidants, Hormetic Nutrition, and Autism. Current Neuropharmacology. 22(7), 1156-1168. https://doi.org/10.2174/1570159X21666230817085811
Keywords
Autism spectrum disorders; CELLULAR STRESS-RESPONSE; SPECTRUM DISORDER
