Journalartikel

Jahr der Veröffentlichung: 2024

Seiten: 107-117

Zeitschrift: Cellular and Molecular Gastroenterology and Hepatology

Bandnummer: 17

Heftnummer: 1

ISSN: 2352-345X

Open Access Status: Green

DOI Link: https://doi.org/10.1016/j.jcmgh.2023.08.014

Verlag: Elsevier

Abstract: 

The control of hepatocellular proliferation by Schistosoma mansoni eggs is an essential aspect of the host-parasite interaction-associated liver damage. The results of the cur-rent study imply that S. mansoni soluble egg antigens trigger the hepatocellular cell cycle and promote proliferation.

BACKGROUND & AIMS: Schistosomiasis is one of the most prominent parasite-induced infectious diseases, affecting more than 250 million people. Schistosoma mansoni causes metabolic exhaustion and a strong redox imbalance in the liver, causing parenchymal damage, and may predispose for cancer. We investigated whether oxidative stress provokes hepatocellular proliferation upon S. mansoni infection.

METHODS: The cell cycle, replication stress response, and proliferation were analyzed on transcriptional and protein levels in the livers of S. mansoni-infected hamsters and by mechanistic gain-and loss-of-function experiments in human hepatoma cells. Major results were validated in human biopsy specimens of S. mansoni-infected patients.

RESULTS: S. mansoni infection induced licensing factors of DNA replication and cell-cycle checkpoint cyclins in parallel with a DNA damage response in hamster hepatocytes. Moreover, even unisexual infection without egg effects, as a reflection of a chronic inflammatory process, resulted in a moderate activa-tion of several cell-cycle markers. S. mansoni soluble egg anti-gens induced proliferation of human hepatoma cells that could be abolished by reduced glutathione.

CONCLUSIONS: Our data suggest that hepatocellular prolifer-ation is triggered by S. mansoni egg-induced oxidative stress.

Harvard-Zitierstil: von Buelow, V., Schneider, M., Dreizler, D., Russ, L., Baier, A., Buss, N., et al. (2024) Schistosoma mansoni-Induced Oxidative Stress Triggers Hepatocellular Proliferation, Cellular and Molecular Gastroenterology and Hepatology, 17(1), pp. 107-117. https://doi.org/10.1016/j.jcmgh.2023.08.014

APA-Zitierstil: von Buelow, V., Schneider, M., Dreizler, D., Russ, L., Baier, A., Buss, N., Lichtenberger, J., Haerle, L., Mueller, H., Tschuschner, A., Schramm, G., Pons-Kuehnemann, J., Grevelding, C., Roeb, E., & Roderfeld, M. (2024). Schistosoma mansoni-Induced Oxidative Stress Triggers Hepatocellular Proliferation. Cellular and Molecular Gastroenterology and Hepatology. 17(1), 107-117. https://doi.org/10.1016/j.jcmgh.2023.08.014