Journal article

Publication year: 2023

Journal: European Cardiology Review

Volume number: 18

ISSN: 1758-3756

Open access status: Gold

DOI Link: https://doi.org/10.15420/ecr.2023.02

Publisher: Radcliffe Medical Media

Abstract: 
Lingering cardiac symptoms are increasingly recognised complications of severe acute respiratory syndrome coronavirus 2 infection, now referred to as post-acute cardiovascular sequelae of COVID-19 (PASC). In the acute phase, cardiac injury is driven by cytokine release and stems from ischaemic and thrombotic complications, resulting in myocardial necrosis. Patients with pre-existing cardiac conditions are particularly vulnerable. Myocarditis due to a direct viral infection is rare. Chronic symptoms relate to either worsening of pre-existing heart disease (PASC - cardiovascular disease) or delayed chronic inflammatory condition due to heterogenous immune dysregulation (PASC - cardiovascular syndrome), the latter affecting a broad segment of previously well people. Both PASC presentations are associated with increased cardiovascular risk, long-term disability and reduced quality of life. The recognition and management of PASC in clinical settings remains a considerable challenge. Sensitive diagnostic methods are needed to detect subtler inflammatory changes that underlie the persistent symptoms in PASC - cardiovascular syndrome, alongside considerable clinical experience in inflammatory cardiac conditions.

Harvard Citation style: Puntmann, V., Shchendrygina, A., Bolanos, C., Ka, M., Valbuena, S., Rolf, A., et al. (2023) Cardiac Involvement Due to COVID-19: Insights from Imaging and Histopathology, European Cardiology Review, 18, Article e58. https://doi.org/10.15420/ecr.2023.02

APA Citation style: Puntmann, V., Shchendrygina, A., Bolanos, C., Ka, M., Valbuena, S., Rolf, A., Escher, F., & Nagel, E. (2023). Cardiac Involvement Due to COVID-19: Insights from Imaging and Histopathology. European Cardiology Review. 18, Article e58. https://doi.org/10.15420/ecr.2023.02