Journal article

Publication year: 2023

Pages: 718-734

Journal: Trends in Endocrinology & Metabolism

Volume number: 34

Issue number: 11

ISSN: 1043-2760

eISSN: 1879-3061

DOI Link: https://doi.org/10.1016/j.tem.2023.08.002

Publisher: Cell Press

Abstract: 
The effects of bile acids (BAs) on liver, enteroendocrine function, small intestine, and brown adipose tissue have been described extensively. Outside the liver, BAs in the peripheral circulation system represent a specific but underappreciated physiological compartment. We discuss how systemic BAs can be regarded as specific steroidal hormones that act on white adipocytes, and suggest the name 'bilokines' ('bile hormones') for the specific FXR/TGR5 receptor interaction in adipocytes. Some BAs and their agonists regulate adipocyte differentiation, lipid accumulation, hypoxia, autophagy, adipokine and cytokine secretion, insulin signaling, and glucose uptake. BA signaling could provide a new therapeutic avenue for adipoflammation and metaflammation in visceral obesity, the causal mechanisms underlying insulin resistance and type 2 diabetes mellitus (T2D).

Harvard Citation style: Schmid, A., Karrasch, T. and Schaeffler, A. (2023) The emerging role of bile acids in white adipose tissue, Trends in Endocrinology & Metabolism, 34(11), pp. 718-734. https://doi.org/10.1016/j.tem.2023.08.002

APA Citation style: Schmid, A., Karrasch, T., & Schaeffler, A. (2023). The emerging role of bile acids in white adipose tissue. Trends in Endocrinology & Metabolism. 34(11), 718-734. https://doi.org/10.1016/j.tem.2023.08.002