Journalartikel

Jahr der Veröffentlichung: 2023

Zeitschrift: International Journal of Molecular Sciences

Bandnummer: 24

Heftnummer: 16

ISSN: 1661-6596

eISSN: 1422-0067

Open Access Status: Gold

DOI Link: https://doi.org/10.3390/ijms241612884

Verlag: MDPI

Abstract: 
The liver, as a central metabolic organ, is systemically linked to metabolic-inflammatory diseases. In the pathogenesis of the metabolic syndrome, inflammatory and metabolic interactions between the intestine, liver, and adipose tissue lead to the progression of hepatic steatosis to metabolic-dysfunction-associated steatohepatitis (MASH) and consecutive MASH-induced fibrosis. Clinical and animal studies revealed that IL-13 might be protective in the development of MASH through both the preservation of metabolic functions and Th2-polarized inflammation in the liver and the adipose tissue. In contrast, IL-13-associated loss of mucosal gut barrier function and IL-13-associated enhanced hepatic fibrosis may contribute to the progression of MASH. However, there are only a few publications on the effect of IL-13 on metabolic diseases and possible therapies to influence them. In this review article, different aspects of IL-13-associated effects on the liver and metabolic liver diseases, which are partly contradictory, are summarized and discussed on the basis of the recent literature.

Harvard-Zitierstil: Roeb, E. (2023) Interleukin-13 (IL-13)-A Pleiotropic Cytokine Involved in Wound Healing and Fibrosis, International Journal of Molecular Sciences, 24(16), Article 12884. https://doi.org/10.3390/ijms241612884

APA-Zitierstil: Roeb, E. (2023). Interleukin-13 (IL-13)-A Pleiotropic Cytokine Involved in Wound Healing and Fibrosis. International Journal of Molecular Sciences. 24(16), Article 12884. https://doi.org/10.3390/ijms241612884