Journalartikel

Jahr der Veröffentlichung: 2023

Seiten: 3-12

Zeitschrift: Seminars in Cell & Developmental Biology

Bandnummer: 135

ISSN: 1084-9521

eISSN: 1096-3634

DOI Link: https://doi.org/10.1016/j.semcdb.2022.03.025

Verlag: Elsevier

Abstract: 
Chromatin, the functional organization of DNA with histone proteins in eukaryotic nuclei, is the tightly-regulated template for several biological processes, such as transcription, replication, DNA damage repair, chromosome stability and sister chromatid segregation. In order to achieve a reversible control of local chromatin structure and DNA accessibility, various interconnected mechanisms have evolved. One of such processes includes the deposition of functionally-diverse variants of histone proteins into nucleosomes, the building blocks of chromatin. Among core histones, the family of H2A histone variants exhibits the largest number of members and highest sequence-divergence. In this short review, we report and discuss recent discoveries concerning the biological functions of the animal histone variants H2A.B, H2A.X and H2A.Z and how dysregulation or mutation of the latter impacts the development of disease.

Harvard-Zitierstil: Herchenröther, A., Wunderlich, T., Lan, J. and Hake, S. (2023) Spotlight on histone H2A variants: From B to X to Z, Seminars in Cell & Developmental Biology, 135, pp. 3-12. https://doi.org/10.1016/j.semcdb.2022.03.025

APA-Zitierstil: Herchenröther, A., Wunderlich, T., Lan, J., & Hake, S. (2023). Spotlight on histone H2A variants: From B to X to Z. Seminars in Cell & Developmental Biology. 135, 3-12. https://doi.org/10.1016/j.semcdb.2022.03.025