Journalartikel

Jahr der Veröffentlichung: 2023

Seiten: 613-620

Zeitschrift: Endocrine

Bandnummer: 81

Heftnummer: 3

ISSN: 1355-008X

eISSN: 1559-0100

DOI Link: https://doi.org/10.1007/s12020-023-03406-7

Verlag: Springer

Abstract: 
PurposeIn women with Polycystic Ovarian Syndrome (PCOS), an increased risk of disordered eating has been described. There is growing interest regarding a possible interconnection between psychological states and increased appetite in women with PCOS. Acute stress is characterized by increased Corticotropin Releasing Hormone (CRH) secretion. The aim was to estimate the ghrelin concentrations during CRH test.MethodsTwenty postmenopausal women with PCOS and twenty age- and BMI- matched postmenopausal control women were recruited at Aretaieion University Hospital. In the morning (9 am) all subjects had anthropometric measurements (weight, height, waist circumference) and a fasting sample for hormonal measurements. An intravenous (iv) CRH stimulation test conducted over 1 min. Serum active ghrelin levels were measured at 0, 15, 30, 60, 90, 120 min after iv CRH administration.ResultsThe postmenopausal PCOS group had a higher waist circumference compared to postmenopausal controls. Active ghrelin concentrations increased significantly from 0 to 15 min, to 30 min, to 60 min, to 90 min and then decreased to 120 min. However, within the postmenopausal control group there were no significant changes in serum active ghrelin levels. Serum active ghrelin concentrations were significantly greater in the postmenopausal control group at 0, 15 and 120 min compared to the postmenopausal PCOS group. At 90 min active ghrelin concentrations were significantly greater in the postmenopausal PCOS group. Delta Area Under the Curve of active ghrelin (Delta AUCghr) was significantly greater in the postmenopausal PCOS group compared to controls.ConclusionsIn postmenopausal PCOS, but not in postmenopausal controls, iv CRH administration induces increased serum active ghrelin secretion, suggesting a possible anti-stress adaptive mechanism. An increase in serum active ghrelin may induce hunger as a side-effect of this presumed adaptive mechanism.

Harvard-Zitierstil: Markopoulos, M., Barber, T., Bargiota, A., Skevaki, C., Papassotiriou, I., Kumar, S., et al. (2023) Acute iv CRH administration significantly increases serum active ghrelin in postmenopausal PCOS women compared to postmenopausal controls, Endocrine, 81(3), pp. 613-620. https://doi.org/10.1007/s12020-023-03406-7

APA-Zitierstil: Markopoulos, M., Barber, T., Bargiota, A., Skevaki, C., Papassotiriou, I., Kumar, S., Vlahos, N., Mastorakos, G., & Valsamakis, G. (2023). Acute iv CRH administration significantly increases serum active ghrelin in postmenopausal PCOS women compared to postmenopausal controls. Endocrine. 81(3), 613-620. https://doi.org/10.1007/s12020-023-03406-7