Journal article

Publication year: 2023

Pages: 96-101

Journal: Journal of Nuclear Medicine

Volume number: 64

Issue number: 1

ISSN: 0161-5505

eISSN: 1535-5667

Open access status: Green

DOI Link: https://doi.org/10.2967/jnumed.122.264112

Publisher: Society of Nuclear Medicine and Molecular Imaging

Abstract: 
18F-FDG PET/MRI might be the diagnostic method of choice for Hodg-kin lymphoma patients, as it combines significant metabolic information from PET with excellent soft-tissue contrast from MRI and avoids radia-tion exposure from CT. However, a major issue is longer examination times than for PET/CT, especially for younger children needing anes-thesia. Thus, a targeted selection of suitable whole-body MRI sequen-ces is important to optimize the PET/MRI workflow. Methods: The initial PET/MRI scans of 84 EuroNet-PHL-C2 study patients from 13 international PET centers were evaluated. In each available MRI sequence, 5 PET-positive lymph nodes were assessed. If extranodal involvement occurred, 2 splenic lesions, 2 skeletal lesions, and 2 lung lesions were also assessed. A detection rate was calculated dividing the number of visible, anatomically assignable, and measurable lesions in the respective MRI sequence by the total number of lesions. Results: Relaxation time-weighted (T2w) transverse sequences with fat satura-tion (fs) yielded the best result, with detection rates of 95% for nodal lesions, 62% for splenic lesions, 94% for skeletal lesions, and 83% for lung lesions, followed by T2w transverse sequences without fs (86%, 49%, 16%, and 59%, respectively) and longitudinal relaxation time- weighted contrast-enhanced transverse sequences with fs (74%, 35%, 57%, and 55%, respectively). Conclusion: T2w transverse sequences with fs yielded the highest detection rates and are well suited for accu-rate whole-body PET/MRI in lymphoma patients. There is no evidence to recommend the use of contrast agents.

Harvard Citation style: Georgi, T., Stoevesandt, D., Kurch, L., Bartelt, J., Hasenclever, D., Dittmann, H., et al. (2023) Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients, Journal of Nuclear Medicine, 64(1), pp. 96-101. https://doi.org/10.2967/jnumed.122.264112

APA Citation style: Georgi, T., Stoevesandt, D., Kurch, L., Bartelt, J., Hasenclever, D., Dittmann, H., Ferda, J., Francis, P., Franzius, C., Furth, C., Graefe, D., Gussew, A., Huellner, M., Menezes, L., Mustafa, M., Stegger, L., Umutlu, L., Zoephel, K., Zucchetta, P., ...Kluge, R. (2023). Optimized Whole-Body PET MRI Sequence Workflow in Pediatric Hodgkin Lymphoma Patients. Journal of Nuclear Medicine. 64(1), 96-101. https://doi.org/10.2967/jnumed.122.264112