Journal article

Publication year: 2023

Journal: Journal of Clinical Medicine

Volume number: 12

Issue number: 10

eISSN: 2077-0383

Open access status: Gold

DOI Link: https://doi.org/10.3390/jcm12103538

Publisher: MDPI

Abstract: 
The negative prognostic value of an increased serum urea-to-albumin ratio on intra-hospital mortality is frequently investigated in general critically ill patients and patients with septic shock, although not in neurosurgical patients with spontaneous intracerebral hemorrhages (ICH). The current study was conducted to investigate the impact of the serum urea-to-albumin ratio upon hospital admission on intra-hospital mortality in ICU-admitted neurosurgical patients with spontaneous ICH. Methods: This retrospective study analyzed 354 ICH patients, who were treated from 10/2008 to 12/2017 at our intensive care units (ICU). Blood samples were taken upon admission, and the patients' demographic, medical, and radiological data were analyzed. A binary logistic regression analysis was performed for the identification of independent prognostic parameters for intra-hospital mortality. Results: Overall, the intra-hospital mortality rate was 31.4% (n = 111). In the binary logistic analysis, a higher serum urea-to-albumin ratio (OR = 1.9, CI = 1.23-3.04, p = 0.005) upon admission was identified as an independent predictor of intra-hospital mortality. Furthermore, a serum urea-to-albumin ratio cut-off level of >0.01 was associated with raised intra-hospital mortality (Youden's index = 0.32, sensitivity = 0.57, specificity = 0.25). Conclusion: A serum urea-to-albumin ratio greater than 1.1 seems to be a prognostic marker to predict intra-hospital mortality in patients with ICH.

Harvard Citation style: Bender, M., Haferkorn, K., Tajmiri-Gondai, S., Stein, M. and Uhl, E. (2023) Serum Urea-to-Albumin Ratio Is an Independent Predictor of Intra-Hospital Mortality in Neurosurgical Intensive Care Unit Patients with Spontaneous Intracerebral Hemorrhage, Journal of Clinical Medicine, 12(10), Article 3538. https://doi.org/10.3390/jcm12103538

APA Citation style: Bender, M., Haferkorn, K., Tajmiri-Gondai, S., Stein, M., & Uhl, E. (2023). Serum Urea-to-Albumin Ratio Is an Independent Predictor of Intra-Hospital Mortality in Neurosurgical Intensive Care Unit Patients with Spontaneous Intracerebral Hemorrhage. Journal of Clinical Medicine. 12(10), Article 3538. https://doi.org/10.3390/jcm12103538