Journal article

Publication year: 2023

Journal: European Respiratory Review

Volume number: 32

Issue number: 167

ISSN: 0905-9180

eISSN: 1600-0617

Open access status: Gold

DOI Link: https://doi.org/10.1183/16000617.0132-2022

Publisher: European Respiratory Society

Abstract: 
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism. It is caused by persistent obstruction of pulmonary arteries by chronic organised fibrotic clots, despite adequate anticoagulation. The pulmonary hypertension is also caused by concomitant microvasculopathy which may progress without timely treatment. Timely and accurate diagnosis requires the combination of imaging and haemodynamic assessment. Optimal therapy should be individualised to each case and determined by an experienced multidisciplinary CTEPH team with the ability to offer all current treatment modalities. This report summarises current knowledge and presents key messages from the International CTEPH Conference, Bad Nauheim, Germany, 2021. Sessions were dedicated to 1) disease definition; 2) pathophysiology, including the impact of the hypertrophied bronchial circulation, right ventricle (dys)function, genetics and inflammation; 3) diagnosis, early after acute pulmonary embolism, using computed tomography and perfusion techniques, and supporting the selection of appropriate therapies; 4) surgical treatment, pulmonary endarterectomy for proximal and distal disease, and peri-operative management; 5) percutaneous approach or balloon pulmonary angioplasty, techniques and complications; and 6) medical treatment, including anticoagulation and pulmonary hypertension drugs, and in combination with interventional treatments. Chronic thromboembolic pulmonary disease without pulmonary hypertension is also discussed in terms of its diagnostic and therapeutic aspects.

Harvard Citation style: Simonneau, G., Fadel, E., Noordegraaf, A., Toshner, M., Lang, I., Klok, F., et al. (2023) Highlights from the International Chronic Thromboembolic Pulmonary Hypertension Congress 2021, European Respiratory Review, 32(167), Article 220132. https://doi.org/10.1183/16000617.0132-2022

APA Citation style: Simonneau, G., Fadel, E., Noordegraaf, A., Toshner, M., Lang, I., Klok, F., McInnis, M., Screaton, N., Madani, M., Martinez, G., Salaunkey, K., Jenkins, D., Matsubara, H., Brenot, P., Hoeper, M., Ghofrani, H., Jais, X., Wiedenroth, C., Guth, S., ...Mayer, E. (2023). Highlights from the International Chronic Thromboembolic Pulmonary Hypertension Congress 2021. European Respiratory Review. 32(167), Article 220132. https://doi.org/10.1183/16000617.0132-2022