Journalartikel

Jahr der Veröffentlichung: 2022

Seiten: 370-380

Zeitschrift: Hämostaseologie

Bandnummer: 42

Heftnummer: 06

ISSN: 0720-9355

eISSN: 2567-5761

Open Access Status: Bronze

DOI Link: https://doi.org/10.1055/s-0042-1757562

Verlag: Thieme Publishing

Abstract: 
Thrombophilia leads to an increased risk of venous thromboembolism. Widely accepted risk factors for thrombophilia comprise deficiencies of protein C, protein S, and antithrombin, as well as the factor V "Leiden " mutation, the prothrombin G20210A mutation, dysfibrinogenemia, and, albeit less conclusive, increased levels of factor VIII. Besides these established markers of thrombophilia, risk factors of unclear significance have been described in the literature. These inherited risk factors include deficiencies or loss-of-activity of the activity of ADAMTS13, heparin cofactor II, plasminogen, tissue factor pathway inhibitor (TFPI), thrombomodulin, protein Z (PZ), as well as PZ-dependent protease inhibitor. On the other hand, thrombophilia has been linked to the gain-of-activity, or elevated levels, of alpha 2-antiplasmin, angiotensin-converting enzyme, coagulation factors IX (FIX) and XI (FXI), fibrinogen, homocysteine, lipoprotein(a), plasminogen activator inhibitor-1 (PAI-1), and thrombin-activatable fibrinolysis inhibitor (TAFI). With respect to the molecular interactions that may influence the thrombotic risk, more complex mechanisms have been described for endothelial protein C receptor (EPCR) and factor XIII (FXIII) Val34Leu. With focus on the risk for venous thrombosis, the present review aims to give an overview on the current knowledge on the significance of the aforementioned markers for thrombophilia screening. According to the current knowledge, there appears to be weak evidence for a potential impact of EPCR, FIX, FXI, FXIII Val34Leu, fibrinogen, homocysteine, PAI-1, PZ, TAFI, and TFPI on the thrombotic risk.

Harvard-Zitierstil: Sachs, U., Kirsch-Altena, A. and Mueller, J. (2022) Markers of Hereditary Thrombophilia with Unclear Significance, Hämostaseologie, 42(06), pp. 370-380. https://doi.org/10.1055/s-0042-1757562

APA-Zitierstil: Sachs, U., Kirsch-Altena, A., & Mueller, J. (2022). Markers of Hereditary Thrombophilia with Unclear Significance. Hämostaseologie. 42(06), 370-380. https://doi.org/10.1055/s-0042-1757562