Journal article

Heat Stress and Histopathological Changes of Vital Organs: A Novel Approach to Assess Climate Resilience in Farm Animals


Authors listRebez, Ebenezer Binuni; Sejian, Veerasamy; Silpa, Mullakkalparambil Velayudhan; Dunshea, Frank R. R.

Publication year2023

JournalSustainability

Volume number15

Issue number2

eISSN2071-1050

Open access statusGold

DOI Linkhttps://doi.org/10.3390/su15021242

PublisherMDPI


Abstract
Heat stress causes functional and metabolic alterations in different cells and tissues. There are several pathomorphological changes and biomarkers associated with head load in adaptive and productive organs of livestock. Heat stress-induced histopathological alterations in livestock were categorized as degenerative changes (fatty degeneration, steatosis, hydropic degeneration), necrosis (pyknosis, fibrosis), circulatory disturbances (hyperemia, edema, hemorrhage, congestion, thrombosis, ischemia), growth disturbances (hyperplasia, atrophy) and focal/diffuse inflammation (vascular changes, exudation). Upon immunohistochemical analysis, the biomarkers identified in growth-related organs were HSP70, HSP60, GABA, GABA(A)R, GABA(B)R, HSP90, GnRH, LH, FSH, m(6)A, Nrf2, and C/EBP beta. The biomarkers in the reproductive organs were HSP70, Bax, Bcl-2, GABA, GABA(A)R, GABA(B)R, Caspase-3, HSP90, HSPB9, HSPB10, HSF1, HSP40, T, E-2, Cyt-C, CAT, BCL2L1, and VEGF. The identified biomarkers in the immune organs were CD3(+) T cells, CD4(+) T cells, CD8(+) T cells, HSP70, and Bcl-2. All these biomarkers could serve as reliable variables in heat stress assessment in livestock. Further, HSP70, HSP90, HSP60, NPY, HSP27, Bcl-2, NF-kappa B, AQP2, Insulin, CD3(+) T cells, CD4(+) T cells, CD172a, EGF, AQP1, AQP3, AQP4, AQP5, CRYAB, GHR, 5-HT, CCK, and GLP-1 are heat stress-related biomarkers in adaptive organs that help in assessing the climate resilience of a livestock species and improving understanding about adaptive mechanisms. Among these biomarkers, HSP70 was established to be the ideal cellular biomarker for scaling heat response in livestock. Thus, examining heat-stressed organ histopathology and identifying cellular markers by immunohistochemistry may lay the foundation for screening climate-resilient livestock breeds in the challenging climatic scenario. Further, such an approach could help in developing concepts to combat the detrimental consequences of heat stress to ensure sustainability in livestock production.



Citation Styles

Harvard Citation styleRebez, E., Sejian, V., Silpa, M. and Dunshea, F. (2023) Heat Stress and Histopathological Changes of Vital Organs: A Novel Approach to Assess Climate Resilience in Farm Animals, Sustainability, 15(2), Article 1242. https://doi.org/10.3390/su15021242

APA Citation styleRebez, E., Sejian, V., Silpa, M., & Dunshea, F. (2023). Heat Stress and Histopathological Changes of Vital Organs: A Novel Approach to Assess Climate Resilience in Farm Animals. Sustainability. 15(2), Article 1242. https://doi.org/10.3390/su15021242



Keywords


ACUTE INTERSTITIAL PNEUMONIABROILER-CHICKENSCORRESPONDING MESSENGER-RNAELEVATED AMBIENT-TEMPERATUREHIGH ENVIRONMENTAL-TEMPERATUREHSP70immunohistochemistryIMPAIRS PERFORMANCE PARAMETERSintestinal morphologyOVARIAN-FUNCTION


SDG Areas


Last updated on 2025-10-06 at 11:49