Journalartikel

Jahr der Veröffentlichung: 2022

Zeitschrift: International Immunopharmacology

Bandnummer: 113

ISSN: 1567-5769

eISSN: 1878-1705

DOI Link: https://doi.org/10.1016/j.intimp.2022.109398

Verlag: Elsevier

Abstract: 
Particulate matter (PM) is a major environmental contaminant that causes and worsens respiratory diseases. Fibroblast growth factor 10 (FGF10), a paracrine fibroblast growth factor that specifically stimulates repair and regeneration after injury, has been shown to protect against PM-induced lung injury. However, the underlying mechanisms are still unclear. In this study, the protective effects of FGF10 were investigated using a PM-induced lung injury mouse model in vivo and BEAS-2B cells in vitro. According to the findings, FGF10 treatment alleviated PM-induced oxidative damage and pyroptosis in vivo and in vitro. Mechanistically, FGF10 activated antioxidative Nrf2 signaling. Inhibition of PI3K signaling with LY294002 or Nrf2 signaling with ML385 revealed that FGF10mediated lung protection was mediated by the PI3K/Akt/Nrf2 pathway. These results collectively indicate that FGF10 inhibits oxidative stress-mediated pyroptosis via the PI3K/Akt/Nrf2 pathway, suggesting a possible therapy for PM-induced lung injury.

Harvard-Zitierstil: Liu, L., Shi, Q., Wang, K., Qian, Y., Zhou, L., Bellusci, S., et al. (2022) Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/ Akt/Nrf2 signaling pathway, International Immunopharmacology, 113, Article 109398. https://doi.org/10.1016/j.intimp.2022.109398

APA-Zitierstil: Liu, L., Shi, Q., Wang, K., Qian, Y., Zhou, L., Bellusci, S., Chen, C., & Dong, N. (2022). Fibroblast growth factor 10 protects against particulate matter-induced lung injury by inhibiting oxidative stress-mediated pyroptosis via the PI3K/ Akt/Nrf2 signaling pathway. International Immunopharmacology. 113, Article 109398. https://doi.org/10.1016/j.intimp.2022.109398