Journal article

Publication year: 2022

Journal: Journal of Clinical Medicine

Volume number: 11

Issue number: 22

eISSN: 2077-0383

Open access status: Gold

DOI Link: https://doi.org/10.3390/jcm11226811

Publisher: MDPI

Abstract: 
(1) Background: ABO blood group incompatibility between the mother and fetus protects against anti-D immunization by pregnancy. The possible role of ABO incompatibility in protecting against anti-human platelet antigen-1a immunization is unclear. (2) Methods: This study retrospectively screened 817 families (mother-father-neonate trios) of suspected fetal and neonatal alloimmune thrombocytopenia for inclusion. ABO genotypes were determined in 118 mother-child pairs with confirmed alloimmune thrombocytopenia due to anti-HPA-1a antibodies, and 522 mother-child pairs served as the control group. The expression of blood group antigen A on platelets was determined in 199 consecutive newborns by flow cytometry and compared with adult controls. (3) Results: ABO incompatibility between mother and fetus did not protect against anti-human platelet antigen-1a immunization by pregnancy. ABO blood groups of mothers and/or fetuses were not associated with the severity of fetal and neonatal alloimmune thrombocytopenia. The expression pattern of blood group A antigens on the platelets of newborns mirrored that of adults, albeit on a lower level. Blood group A antigen was detected on a subpopulation of neonatal platelets, and some newborns revealed high platelet expression of A determinants on all platelets (type II high-expressers). (4) Conclusion: The lack of a protective effect of ABO incompatibility between mother and fetus against anti-human platelet antigen-1a immunization by pregnancy may indicate that fetal platelets are not the cellular source by which the mother is immunized.

Harvard Citation style: Miserre, L., Wienzek-Lischka, S., Mann, A., Cooper, N., Santoso, S., Ehrhardt, H., et al. (2022) ABO Incompatibility between the Mother and Fetus Does Not Protect against Anti-Human Platelet Antigen-1a Immunization by Pregnancy, Journal of Clinical Medicine, 11(22), Article 6811. https://doi.org/10.3390/jcm11226811

APA Citation style: Miserre, L., Wienzek-Lischka, S., Mann, A., Cooper, N., Santoso, S., Ehrhardt, H., Sachs, U., & Bein, G. (2022). ABO Incompatibility between the Mother and Fetus Does Not Protect against Anti-Human Platelet Antigen-1a Immunization by Pregnancy. Journal of Clinical Medicine. 11(22), Article 6811. https://doi.org/10.3390/jcm11226811