Journalartikel

Polypoidal Choroidal Vasculopathy Based on Non-ICGA Criteria in White Patients With Neovascular Age-Related Macular Degeneration


AutorenlisteChaikitmongkol, Voraporn; Ozimek, Malgorzata; Srisomboon, Titipol; Patikulsila, Direk; Fraser-bell, Samantha; Chhablani, Jay; Choovuthayakorn, Janejit; Watanachai, Nawat; Kunavisarut, Paradee; Rodriguez-Valdes, Patricio J.; Lozano-Rechy, David; Lupidi, Marco; Al-Sheikh, Mayss; Fung, Adrian T.; Busch, Catharian; Mehta, Hemal; Gabrielle, Pierre-Henry; Zur, Dinah; Ramon, Dan; Sangkaew, Apisara; Ingviya, Thammasin; Amphornprut, Atchara; Cebeci, Zafer; Couturier, Aude; Mendes, Thais Sousa; Giancipoli, Ermete; Iglicki, Matias; Invernizzi, Alessandro; Lains, Ines; Rehak, Matus; Sala-Puigdollers, Anna; Okada, Mali; Loewenstein, Anat; Bressler, Neil M.

Jahr der Veröffentlichung2022

Seiten58-67

ZeitschriftAmerican Journal of Ophthalmology

Bandnummer244

ISSN0002-9394

eISSN1879-1891

DOI Linkhttps://doi.org/10.1016/j.ajo.2022.07.024

VerlagElsevier


Abstract
PURPOSE: To determine prevalence of probable poly-poidal choroidal vasculopathy (PCV) among White patients with neovascular age-related macular degeneration (nAMD) using non-indocyanine green angiography (ICGA) criteria & BULL; DESIGN: Multicenter, multinational, retrospective, cross-sectional study. METHODS: A total of 208 treatmentnaive eyes from Hispanic and non-Hispanic White individuals diagnosed with nAMD were included. All underwent color fundus photography (CFP), optical coherence tomography (OCT), and fluorescein angiography (FFA). De-identified images of study eyes were sent to 2 groups of graders. Group 1 reviewed CFP, OCT, and FFA to confirm nAMD diagnosis. Group 2 reviewed CFP and OCT to determine highly suggestive features for PCV. Probable PCV diagnosis defined as the presence of > 2 of 4 highly suggestive features for PCV: notched or fibrovascular pigment epithelial detachment (PED) on CFP, sharply-peaked PED, notched PED, and hyperreflective ring on OCT. RESULTS: Eleven eyes were excluded because of poor image quality (6) or non-nAMD diagnosis (5). Of 197 eligible eyes (197 patients), the mean age (SD) was 78.8 years (8.9), 44.2% were men, 26.4% were Hispanic, and 73.6% were non-Hispanic White individuals; 41.1%, 23.4%, 9.1%, and 2.5% had > 1, > 2, > 3, and 4 highly suggestive features. Results showed that 23.4% (95% CI, 17.6%-29.9%) had probable PCV diagnosis. Pre-dominantly occult CNV was more frequently found in probable PCV than nAMD subgroup (84.8% vs 64.9%, P = .01). Hispanic White individuals had a lower prevalence of probable PCV than non-Hispanic White individuals (9.6% vs 28.2%, P = .006) CONCLUSIONS: These findings suggest that probable PCV occurs between 17.6% and 29.9% in White individuals with nAMD, and more commonly in non-Hispanic than in Hispanic White individuals. (C) 2022 Elsevier Inc. All rights reserved.)



Zitierstile

Harvard-ZitierstilChaikitmongkol, V., Ozimek, M., Srisomboon, T., Patikulsila, D., Fraser-bell, S., Chhablani, J., et al. (2022) Polypoidal Choroidal Vasculopathy Based on Non-ICGA Criteria in White Patients With Neovascular Age-Related Macular Degeneration, American Journal of Ophthalmology, 244, pp. 58-67. https://doi.org/10.1016/j.ajo.2022.07.024

APA-ZitierstilChaikitmongkol, V., Ozimek, M., Srisomboon, T., Patikulsila, D., Fraser-bell, S., Chhablani, J., Choovuthayakorn, J., Watanachai, N., Kunavisarut, P., Rodriguez-Valdes, P., Lozano-Rechy, D., Lupidi, M., Al-Sheikh, M., Fung, A., Busch, C., Mehta, H., Gabrielle, P., Zur, D., Ramon, D., ...Bressler, N. (2022). Polypoidal Choroidal Vasculopathy Based on Non-ICGA Criteria in White Patients With Neovascular Age-Related Macular Degeneration. American Journal of Ophthalmology. 244, 58-67. https://doi.org/10.1016/j.ajo.2022.07.024



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JAPANESERANIBIZUMABVERTEPORFIN PHOTODYNAMIC THERAPY


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