Journal article

Publication year: 2022

Journal: Cells

Volume number: 11

Issue number: 13

eISSN: 2073-4409

Open access status: Gold

DOI Link: https://doi.org/10.3390/cells11132121

Publisher: MDPI

Abstract: 
Chronic obstructive pulmonary disease (COPD) is a disease with an inflammatory phenotype with increasing prevalence in the elderly. Expanded population of mutant blood cells carrying somatic mutations is termed clonal hematopoiesis of indeterminate potential (CHIP). The association between CHIP and COPD and its relevant effects on DNA methylation in aging are mainly unknown. Analyzing the deep-targeted amplicon sequencing from 125 COPD patients, we found enhanced incidence of CHIP mutations (similar to 20%) with a predominance of DNMT3A CHIP-mediated hypomethylation of Phospholipase D Family Member 5 (PLD5), which in turn is positively correlated with increased levels of glycerol phosphocholine, pro-inflammatory cytokines, and deteriorating lung function.

Harvard Citation style: Kuhnert, S., Mansouri, S., Rieger, M., Savai, R., Avci, E., Diaz-Pina, G., et al. (2022) Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD, Cells, 11(13), Article 2121. https://doi.org/10.3390/cells11132121

APA Citation style: Kuhnert, S., Mansouri, S., Rieger, M., Savai, R., Avci, E., Diaz-Pina, G., Padmasekar, M., Looso, M., Hadzic, S., Acker, T., Klatt, S., Wilhelm, J., Fleming, I., Sommer, N., Weissmann, N., Vogelmeier, C., Bals, R., Zeiher, A., Dimmeler, S., ...Pullamsetti, S. (2022). Association of Clonal Hematopoiesis of Indeterminate Potential with Inflammatory Gene Expression in Patients with COPD. Cells. 11(13), Article 2121. https://doi.org/10.3390/cells11132121