Journal article

Publication year: 2022

Pages: 1117-1126

Journal: Pediatric Pulmonology

Volume number: 57

Issue number: 5

ISSN: 8755-6863

eISSN: 1099-0496

Open access status: Hybrid

DOI Link: https://doi.org/10.1002/ppul.25868

Publisher: Wiley

Abstract: 
Aim To evaluate safety and clinical outcome of rapid enteral feeding advances in preterm infants <1500 g birthweight (BW). Methods In this single-center retrospective cohort study, 293 preterm infants born during 2015-2018 were comparatively analyzed before (n = 145) and after (n = 148) the implementation of a rapid enteral feeding protocol with daily milk increments of 20-30 ml/kg of body weight. Major outcome parameters were focused toward pulmonary morbidities and nutritional variables. Results Preterm infants in the rapid feeding advancement group were more successfully stabilized on noninvasive ventilation (p < 0.001) never requiring mechanical ventilation. Duration of respiratory support (0.465) and frequency of bronchopulmonary dysplasia (BPD) (p = 0.341) and severe BPD (0.273) did not differ between both groups. Furthermore, patients in the rapid feeding group achieved full volume feedings faster (p < 0.001), regained BW earlier (p = 0.009), and displayed significantly improved somatic growth at 36 weeks gestational age (p < 0.001). There was no increased risk for further morbidities of prematurity including feeding intolerance, necrotizing enterocolitis (NEC), and focal intestinal perforation. Conclusion Rapid enteral feeding advancements in preterm infants <1500 g BW are safe and do not impede stabilization on noninvasive ventilation.

Harvard Citation style: Behnke, J., Estreich, V., Oehmke, F., Zimmer, K., Windhorst, A. and Ehrhardt, H. (2022) Compatibility of rapid enteral feeding advances and noninvasive ventilation in preterm infants-An observational study, Pediatric Pulmonology, 57(5), pp. 1117-1126. https://doi.org/10.1002/ppul.25868

APA Citation style: Behnke, J., Estreich, V., Oehmke, F., Zimmer, K., Windhorst, A., & Ehrhardt, H. (2022). Compatibility of rapid enteral feeding advances and noninvasive ventilation in preterm infants-An observational study. Pediatric Pulmonology. 57(5), 1117-1126. https://doi.org/10.1002/ppul.25868