Journal article

Publication year: 2021

Journal: Acta Dermato-Venereologica

Volume number: 101

ISSN: 0001-5555

eISSN: 1651-2057

Open access status: Gold

DOI Link: https://doi.org/10.2340/00015555-3887

Publisher: Medical Journals Sweden

Abstract: 
Data on vitamin D status of patients with inherited ichthyosis in Europe is scarce and unspecific concerning the genetic subtype. This study determined serum levels of 25-hydroxyvitamin D3 (25(OH)D3) in 87 patients with ichthyosis; 69 patients were additionally analysed for parathyroid hormone. Vitamin D deficiency was pronounced in keratinopathic ichthyosis (n = 17; median 25(OH)D3: 10.5 ng/ml), harlequin ichthyosis (n = 2;7.0 ng/ml) and rare syndromic subtypes (n = 3; 7.0 ng/ml). Vitamin D levels were reduced in TG1-proficient lamellar ichthyosis (n = 15; 8.9 ng/ml), TG1-deficient lamellar ichthyosis (n = 12; 11.7 ng/ml), congenital ichthyosiform erythroderma (n = 13; 12.4 ng/ml), Netherton syndrome (n = 7; 10.7 ng/ml) and X-linked ichthyosis (n = 8; 13.9 ng/ml). In ichthyosis vulgaris 25(OH)D3 levels were higher (n = 10; 19.7 ng/ml). Parathyroid hormone was elevated in 12 patients. Low 25(OH)D3 levels were associated with high severity of scaling (p = 0.03) implicating scaling as a risk factor for vitamin D deficiency. Thus, this study supports our recent guidelines for ichthyoses, which recommend screening for and substituting of vitamin D deficiency.

Harvard Citation style: Kim, M., Oji, V., Valentin, F., Traupe, H., Nofer, J., Hausser, I., et al. (2021) Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling, Acta Dermato-Venereologica, 101, Article adv00546. https://doi.org/10.2340/00015555-3887

APA Citation style: Kim, M., Oji, V., Valentin, F., Traupe, H., Nofer, J., Hausser, I., Hennies, H., Eckl, K., Wudy, S., Sanchez-Guijo, A., Kerschke, L., Fischer, J., & Suessmuth, K. (2021). Vitamin D Status in Distinct Types of Ichthyosis: Importance of Genetic Type and Severity of Scaling. Acta Dermato-Venereologica. 101, Article adv00546. https://doi.org/10.2340/00015555-3887