Journal article
Authors list: Gross, Miriam; Speckmann, Carsten; May, Annette; Gajardo-Carrasco, Tania; Wustrau, Katharina; Maier, Sarah Lena; Panning, Marcus; Huzly, Daniela; Agaimy, Abbas; Bryceson, Yenan T.; Choo, Sharon; Chow, C. W.; Dueckers, Gregor; Fasth, Anders; Fraitag, Sylvie; Graewe, Katja; Haxelmans, Sabine; Holzinger, Dirk; Hudowenz, Ole; Huebschen, Judith M.; Khurana, Claudia; Kienle, Korbinian; Klifa, Roman; Korn, Klaus; Kutzner, Heinz; Laemmermann, Tim; Ledig, Svea; Lipsker, Dan; Meeths, Marie; Naumann-Bartsch, Nora; Rascon, Jelena; Schaenzer, Anne; Seidl, Maximilian; Tesi, Bianca; Vauloup-Fellous, Christelle; Vollmer-Kary, Beate; Warnatz, Klaus; Wehr, Claudia; Neven, Benedicte; Vargas, Pablo; Sepulveda, Fernando E.; Lehmberg, Kai; Schmitt-Graeff, Annette; Ehl, Stephan
Publication year: 2022
Pages: 388-38+
Journal: Journal of Allergy and Clinical Immunology
Volume number: 149
Issue number: 1
ISSN: 0091-6749
eISSN: 1097-6825
DOI Link: https://doi.org/10.1016/j.jaci.2021.05.007
Publisher: Elsevier
Abstract:
Background: Rubella virus-induced granulomas have been described in patients with various inborn errors of immunity. Most defects impair T-cell immunity, suggesting a critical role of T cells in rubella elimination. However, the molecular mechanism of virus control remains elusive. Objective: This study sought to understand the defective effector mechanism allowing rubella vaccine virus persistence in granulomas. Methods: Starting from an index case with Griscelli syndrome type 2 and rubella skin granulomas, this study combined an international survey with a literature search to identify patients with cytotoxicity defects and granuloma. The investigators performed rubella virus immunohistochemistry and PCR and T-cell migration assays. Results: This study identified 21 patients with various genetically confirmed cytotoxicity defects, who presented with
Citation Styles
Harvard Citation style: Gross, M., Speckmann, C., May, A., Gajardo-Carrasco, T., Wustrau, K., Maier, S., et al. (2022) Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity, Journal of Allergy and Clinical Immunology, 149(1), pp. 388-38+. https://doi.org/10.1016/j.jaci.2021.05.007
APA Citation style: Gross, M., Speckmann, C., May, A., Gajardo-Carrasco, T., Wustrau, K., Maier, S., Panning, M., Huzly, D., Agaimy, A., Bryceson, Y., Choo, S., Chow, C., Dueckers, G., Fasth, A., Fraitag, S., Graewe, K., Haxelmans, S., Holzinger, D., Hudowenz, O., ...Ehl, S. (2022). Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity. Journal of Allergy and Clinical Immunology. 149(1), 388-38+. https://doi.org/10.1016/j.jaci.2021.05.007
Keywords
DENDRITIC CELL-MIGRATION; Griscelli syndrome type 2; hemophagocytic lymphohistiocytosis; live vaccine; LYMPHOCYTE-MEDIATED CYTOTOXICITY; NATURAL-KILLER; PARTIAL ALBINISM; PERFORIN; primary immunodeficiency; rubella virus
