Journal article

Publication year: 2021

Journal: Diagnostics

Volume number: 11

Issue number: 12

eISSN: 2075-4418

Open access status: Gold

DOI Link: https://doi.org/10.3390/diagnostics11122188

Publisher: MDPI

Abstract: 
The main aim of this study was to assess the prognostic utility of TAPSE/PASP as an echocardiographic parameter of maladaptive RV remodeling in cardiomyopathy patients using cardiac magnetic resonance (CMR) imaging. Furthermore, we sought to compare TAPSE/PASP to TAPSE. The association of the echocardiographic parameters TAPSE/PASP and TAPSE with CMR parameters of RV and LV remodeling was evaluated in 111 patients with ischemic and non-ischemic cardiomyopathy and cut-off values for maladaptive RV remodeling were defined. In a second step, the prognostic value of TAPSE/PASP and its cut-off value were analyzed regarding mortality in a validation cohort consisting of 221 patients with ischemic and non-ischemic cardiomyopathy. A low TAPSE/PASP (<0.38 mm/mmHg) and TAPSE (<16 mm) were associated with a lower RVEF and a long-axis RV global longitudinal strain (GLS) as well as higher RVESVI, RVEDVI and NT-proBNP. A low TAPSE/PASP, but not TAPSE, was associated with a lower LVEF and long-axis LV GLS, and a higher LVESVI, LVEDVI and T1 relaxation time at the interventricular septum and the RV insertion points. Furthermore, in the validation cohort, low TAPSE/PASP was associated with a higher mortality and TAPSE/PASP was an independent predictor of mortality. TAPSE/PASP is a predictor of maladaptive RV and LV remodeling associated with poor outcomes in cardiomyopathy patients.

Harvard Citation style: Keranov, S., Haen, S., Vietheer, J., Rutsatz, W., Wolter, J., Kriechbaum, S., et al. (2021) Application and Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio in Patients with Ischemic and Non-Ischemic Cardiomyopathy, Diagnostics, 11(12), Article 2188. https://doi.org/10.3390/diagnostics11122188

APA Citation style: Keranov, S., Haen, S., Vietheer, J., Rutsatz, W., Wolter, J., Kriechbaum, S., von Jeinsen, B., Bauer, P., Tello, K., Richter, M., Doerr, O., Rieth, A., Nef, H., Hamm, C., Liebetrau, C., Rolf, A., & Keller, T. (2021). Application and Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio in Patients with Ischemic and Non-Ischemic Cardiomyopathy. Diagnostics. 11(12), Article 2188. https://doi.org/10.3390/diagnostics11122188