Journal article

Publication year: 2021

Pages: 771-777

Journal: Iranian Journal of Allergy, Asthma and Immunology

Volume number: 20

Issue number: 6

ISSN: 1735-1502

eISSN: 1735-5249

Open access status: Gold

DOI Link: https://doi.org/10.18502/ijaai.v20i6.8029

Publisher: Tehran University of Medical Sciences

Abstract: 
Autoimmune neutropenia is a type of immune-mediated neutropenia, caused by antibodyinduced neutrophil destruction. Here, we report two cases (a 3-year-old boy and a 9-year-old girl) with suspected autoimmune neutropenia. The presence of neutrophil antibodies in the sera of these two patients was investigated; using standard neutrophil antibody screening tests such as granulocyte immunofluorescence test (GIFT), granulocyte agglutination test (GAT), and lymphocyte immunofluorescence test (LIFT). A positive reactivity with two-panel cells was found in GIFT. No reactivities with panel cells were observed in GAT and LIFT. To the best of our knowledge, this is the first report for detecting the neutrophil reactive antibodies; using genotyped neutrophils in patients with autoimmune neutropenia in Iran. The final diagnosis of our patients was primary autoimmune neutropenia for the boy and autoimmune neutropenia associated with familial Mediterranean fever for the girl.

Harvard Citation style: Esmaeili, B., Bayat, B., Fazlollahi, M., Moradi, L., Kalantari, A., Nourbakhsh, S., et al. (2021) Identification of Antibodies against Neutrophil Surface Antigens in Two Iranian Patients with Autoimmune Neutropenia, Iranian Journal of Allergy, Asthma and Immunology, 20(6), pp. 771-777. https://doi.org/10.18502/ijaai.v20i6.8029

APA Citation style: Esmaeili, B., Bayat, B., Fazlollahi, M., Moradi, L., Kalantari, A., Nourbakhsh, S., & Pourpak, Z. (2021). Identification of Antibodies against Neutrophil Surface Antigens in Two Iranian Patients with Autoimmune Neutropenia. Iranian Journal of Allergy, Asthma and Immunology. 20(6), 771-777. https://doi.org/10.18502/ijaai.v20i6.8029