Journal article

Publication year: 2021

Pages: E87-E92

Journal: Journal of Cystic Fibrosis

Volume number: 20

Issue number: 6

ISSN: 1569-1993

eISSN: 1873-5010

Open access status: Hybrid

DOI Link: https://doi.org/10.1016/j.jcf.2021.05.003

Publisher: Elsevier

Abstract: 
Background: Epidemiology and potential risk factors for cystic fibrosis arthropathy (CFA) were studied in a relevant cystic fibrosis (CF) patient cohort. Methods: Cohort study of patients included in the German CF registry in 2016-2017. Descriptive analysis, exploratory tests and multivariable logistic regression were used to assess prevalence of CFA and associated potential risk factors for adult patients with/without chronic Pseudomonas aeruginosa infection. Results: 6069 CF patients aged from 0 to 78 years were analysed. CFA was observed in 4.9% of the patients. Prevalence was significantly higher in adult patients (8.4%) compared to patients < 18 years (0.7%; p < 0.0 0 01). Logistic regression analyses in adult patients (n = 3319) showed that CFA was significantly associated with increasing age (OR = 1.04; 95% CI: 1.02-1.05; p < 0.0 0 01), female gender (OR = 2.10; 95%CI:1.52-2.90; p < 0.0 0 01), number of hospitalizations (OR = 1.24; 95%CI:1.12-1.36; p < 0.0 0 01), chronic P. aeruginosa infection (OR = 1.83; 95%CI:1.28-2.61; p = 0.0 0 09), CF-related diabetes (OR = 1.69; 95%CI:1.232.33; p = 0.0013), pancreatic insufficiency (OR = 2.39; 95%CI:1.28-4.46; p = 0.0060) and sinusitis/polyps (OR = 1.91; 95%CI:1.39-2.62; p < 0.0 0 01). In a subgroup analysis of adults without chronic P. aeruginosa infection (n = 1550) CFA was also significantly associated with increasing age, female gender, increasing number of hospitalizations, pancreatic insufficiency as well as sinusitis/polyps; antimycotic treatment associated only in this subgroup while association with CF-related diabetes was not significant. Conclusion: CFA is a frequent and clinically relevant co-morbidity particularly in adult CF patients. CFA is significantly more common in patients with chronic P. aeruginosa colonization but associations with other indicators for a more severe disease course were identified regardless of P. aeruginosa colonization status. (c) 2021 The Authors. Published by Elsevier B.V. on behalf of European Cystic Fibrosis Society. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

Harvard Citation style: Grehn, C., Dittrich, A., Wosniok, J., Holz, F., Hafkemeyer, S., Naehrlich, L., et al. (2021) Risk factors for cystic fibrosis arthropathy: Data from the German cystic fibrosis registry, Journal of Cystic Fibrosis, 20(6), pp. E87-E92. https://doi.org/10.1016/j.jcf.2021.05.003

APA Citation style: Grehn, C., Dittrich, A., Wosniok, J., Holz, F., Hafkemeyer, S., Naehrlich, L., & Schwarz, C. (2021). Risk factors for cystic fibrosis arthropathy: Data from the German cystic fibrosis registry. Journal of Cystic Fibrosis. 20(6), E87-E92. https://doi.org/10.1016/j.jcf.2021.05.003