Journal article

Publication year: 2021

Pages: 1273-1282

Journal: Journal of Pediatric Endocrinology and Metabolism

Volume number: 34

Issue number: 10

ISSN: 0334-018X

eISSN: 2191-0251

DOI Link: https://doi.org/10.1515/jpem-2021-0254

Publisher: De Gruyter

Abstract: 
Objectives: Obesity has often been associated with high low-density-lipoprotein cholesterol (LDL-C) and triglycer-ide plasma concentrations, known risk factors for diabetes mellitus and cardiovascular disease. Study objective was to evaluate the association of LDL-C and triglyceride plasma concentration with muscle and fat mass in children and adolescents. Methods: We analyzed data of the National Health and Nutrition Examination Survey (1999-2004) to estimate lean muscle and fat mass assessed by dual-energy X-ray absorptiometry (DXA) of participants whose lipid profiles had been examined. Fat mass was operationalized by DXA-determined fat mass index (FMI). Muscle mass was assessed by appendicular lean mass index (aLMI). High LDL-C and triglyceride concentration was defined as above 130 mg/dL. Results: For the evaluation of the association of LDL-C and triglyceride plasma concentration with LMI and FMI Z-scores, the data of 2,487 children and adolescents (age 8-19 years) (984 females) were eligible. High aLMI showed no association with LDL-C or triglyceride concentration, but high FMI showed significant association with LDL-C and triglyceride plasma concentration in the bivariate regression analysis. Conclusions: Isolated muscle mass increase may not be protective against high LDL-C and triglycerides plasma levels in children and adolescents. Thus, exercise may lead to risk factor reduction mainly through fat mass reduction.

Harvard Citation style: Martakis, K., Stark, C., Rehberg, M., Jackels, M., Schoenau, E. and Duran, I. (2021) Association of muscle mass and fat mass on low- density-lipoprotein cholesterol and triglyceride plasma concentration in children and adolescents, Journal of Pediatric Endocrinology and Metabolism, 34(10), pp. 1273-1282. https://doi.org/10.1515/jpem-2021-0254

APA Citation style: Martakis, K., Stark, C., Rehberg, M., Jackels, M., Schoenau, E., & Duran, I. (2021). Association of muscle mass and fat mass on low- density-lipoprotein cholesterol and triglyceride plasma concentration in children and adolescents. Journal of Pediatric Endocrinology and Metabolism. 34(10), 1273-1282. https://doi.org/10.1515/jpem-2021-0254