Journalartikel

Jahr der Veröffentlichung: 2021

Seiten: 430-437

Zeitschrift: ZUCHTUNGSKUNDE

Bandnummer: 93

Heftnummer: 6

ISSN: 0044-5401

eISSN: 1867-4518

Verlag: EUGEN ULMER GMBH CO

Abstract: 
The aim of this study was to establish a method to measure the immune response after vaccination with antigens of the footrot pathogen Dichelobacter nodosus, and to assess the suitability of this phenotype as potential selection trait in sheep. An enzyme-linked immunosorbent assay (ELISA) including D. nodosus antigens extracted from a commercial footrot vaccine was developed. With this ELISA, antibody titers were measured in blood samples collected from female Merinoland sheep at several time points after vaccination. The animals were vaccinated with the commercial vaccine at 5-8 months of age and a second time four weeks later. Antibody titer data from 202 Merinoland sheep, belonging to 7 half-sib groups, were included in the analyses. In all sheep, antibody titers increased after vaccination to a peak two weeks after the booster vaccination, followed by a slower decrease. Sheep from three compared half-sib groups showed different persistence of antibody titer with significantly different antibody titers at late time points (week 16 and 28 after primary vaccination). Heritabilities for antibody titers estimated with animal and sire model were high two weeks after primary vaccination (0.69 and 0.81, respectively) and decreased in the time course to medium values (0.25 and 0.37 at week 28). Because of the relative short protective effect of footrot vaccination, the most promising use of antibody titers measured after vaccination for breeding could be to increase the persistence of the vaccine response. However, further investigations are necessary before a practical application may be considered.

Harvard-Zitierstil: Amend, A., Adeniyi, O., Wagner, H. and Luehken, G. (2021) Antibody titer after vaccination as potential breeding target against footrot in sheep, ZUCHTUNGSKUNDE, 93(6), pp. 430-437

APA-Zitierstil: Amend, A., Adeniyi, O., Wagner, H., & Luehken, G. (2021). Antibody titer after vaccination as potential breeding target against footrot in sheep. ZUCHTUNGSKUNDE. 93(6), 430-437.