Journalartikel

Jahr der Veröffentlichung: 2021

Zeitschrift: International Journal of Molecular Sciences

Bandnummer: 22

Heftnummer: 20

eISSN: 1422-0067

Open Access Status: Gold

DOI Link: https://doi.org/10.3390/ijms222011006

Verlag: MDPI

Abstract: 
In utero, the fetus and its lungs develop in a hypoxic environment, where HIF-1 alpha and VEGFA signaling constitute major determinants of further development. Disruption of this homeostasis after preterm delivery and extrauterine exposure to high fractions of oxygen are among the key events leading to bronchopulmonary dysplasia (BPD). Reactive oxygen species (ROS) production constitutes the initial driver of pulmonary inflammation and cell death, altered gene expression, and vasoconstriction, leading to the distortion of further lung development. From preclinical studies mainly performed on rodents over the past two decades, the deleterious effects of oxygen toxicity and the injurious insults and downstream cascades arising from ROS production are well recognized. This article provides a concise overview of disease drivers and different therapeutic approaches that have been successfully tested within experimental models. Despite current studies, clinical researchers are still faced with an unmet clinical need, and many of these strategies have not proven to be equally effective in clinical trials. In light of this challenge, adapting experimental models to the complexity of the clinical situation and pursuing new directions constitute appropriate actions to overcome this dilemma. Our review intends to stimulate research activities towards the understanding of an important issue of immature lung injury.

Harvard-Zitierstil: Choi, Y., Rekers, L., Dong, Y., Holzfurtner, L., Goetz, M., Shahzad, T., et al. (2021) Oxygen Toxicity to the Immature Lung-Part I: Pathomechanistic Understanding and Preclinical Perspectives, International Journal of Molecular Sciences, 22(20), Article 11006. https://doi.org/10.3390/ijms222011006

APA-Zitierstil: Choi, Y., Rekers, L., Dong, Y., Holzfurtner, L., Goetz, M., Shahzad, T., Zimmer, K., Behnke, J., Behnke, J., Bellusci, S., & Ehrhardt, H. (2021). Oxygen Toxicity to the Immature Lung-Part I: Pathomechanistic Understanding and Preclinical Perspectives. International Journal of Molecular Sciences. 22(20), Article 11006. https://doi.org/10.3390/ijms222011006