Journal article
Authors list: Schulz-Weidner, Nelly; Weigel, Markus; Turujlija, Filip; Komma, Kassandra; Mengel, Jan Philipp; Schlenz, Maximiliane Amelie; Bulski, Julia Camilla; Kraemer, Norbert; Hain, Torsten
Publication year: 2021
Journal: Microorganisms
Volume number: 9
Issue number: 9
eISSN: 2076-2607
Open access status: Gold
DOI Link: https://doi.org/10.3390/microorganisms9091904
Publisher: MDPI
Abstract:
Oral bacteria have been associated with several systemic diseases. Moreover, the abundance of bacteria associated with caries has been found to be higher in patients with congenital heart disease (CHD) than in healthy control groups (HCGs). Therefore, this study aimed to evaluate the dental microbiota in children with CHD compared to a HCG. The aim was to describe and compare the carious microbiome regarding the composition, diversity, and taxonomic patterns in these two groups. Twenty children with CHD and a HCG aged between two and six years participated. All of them were affected by early childhood caries. Microbiome profiling indicated that Fusobacterium, Prevotella, Capnocytophaga, and Oribacterium were more abundant in the CHD group, whereas Lactobacillus and Rothia were predominant in the HCG. Furthermore, microbiome analysis revealed three distinct clusters for the CHD and HCG samples. In the first cluster, we found mainly the genera Lactobacillus and Coriobacteriaceae. The second cluster showed a higher relative abundance of the genus Actinomyces and a more diverse composition consisting of more genera with a smaller relative lot. The third cluster was characterized by two genera, Streptococcus and Veillonella. These data can help us to understand the oral microbial community structures involved in caries and endodontic infections of pre-school children in relation to the general health of these high-risk patients.
Citation Styles
Harvard Citation style: Schulz-Weidner, N., Weigel, M., Turujlija, F., Komma, K., Mengel, J., Schlenz, M., et al. (2021) Microbiome Analysis of Carious Lesions in Pre-School Children with Early Childhood Caries and Congenital Heart Disease, Microorganisms, 9(9), Article 1904. https://doi.org/10.3390/microorganisms9091904
APA Citation style: Schulz-Weidner, N., Weigel, M., Turujlija, F., Komma, K., Mengel, J., Schlenz, M., Bulski, J., Kraemer, N., & Hain, T. (2021). Microbiome Analysis of Carious Lesions in Pre-School Children with Early Childhood Caries and Congenital Heart Disease. Microorganisms. 9(9), Article 1904. https://doi.org/10.3390/microorganisms9091904
Keywords
congenital heart disease; dentinal microbiome; DYSBIOSIS; early childhood caries; INFECTIVE ENDOCARDITIS; Oral health; oral microbiome; pediatric dentistry; STREPTOCOCCUS; TEETH
