Journal article

Publication year: 2022

Pages: 948-957

Journal: Journal of Gastrointestinal Cancer

Volume number: 53

Issue number: 4

ISSN: 1941-6628

eISSN: 1941-6636

Open access status: Hybrid

DOI Link: https://doi.org/10.1007/s12029-021-00703-0

Publisher: Springer

Abstract: 
Purpose Early detection of adenocarcinomas in the esophagus is crucial for achieving curative endoscopic therapy. Targeted biopsies of suspicious lesions, as well as four-quadrant biopsies, represent the current diagnostic standard. However, this procedure is time-consuming, cost-intensive, and examiner-dependent. The aim of this study was to test whether impedance spectroscopy is capable of distinguishing between healthy, premalignant, and malignant lesions. An ex vivo measurement method was developed to examine esophageal lesions using impedance spectroscopy immediately after endoscopic resection. Methods After endoscopic resection of suspicious lesions in the esophagus, impedance measurements were performed on resected cork-covered tissue using a measuring head that was developed, with eight gold electrodes, over 10 different measurement settings and with frequencies from 100 Hz to 1 MHz. Results A total of 105 measurements were performed in 60 patients. A dataset of 400 per investigation and a total of more than 42,000 impedance measurements were therefore collected. Electrical impedance spectroscopy (EIS) was able to detect dysplastic esophageal mucosa with a sensitivity of 81% in Barrett's esophagus. Conclusion In summary, EIS was able to distinguish different tissue characteristics in the different esophageal tissues. EIS thus holds potential for further development of targeted biopsies during surveillance endoscopy. Trial Registration NCT04046601

Harvard Citation style: Bloesser, S., May, A., Welsch, L., Ast, M., Braun, S., Velten, T., et al. (2022) Virtual Biopsy by Electrical Impedance Spectroscopy in Barrett's Carcinoma, Journal of Gastrointestinal Cancer, 53(4), pp. 948-957. https://doi.org/10.1007/s12029-021-00703-0

APA Citation style: Bloesser, S., May, A., Welsch, L., Ast, M., Braun, S., Velten, T., Biehl, M., Tschammer, J., Roeb, E., & Knabe, M. (2022). Virtual Biopsy by Electrical Impedance Spectroscopy in Barrett's Carcinoma. Journal of Gastrointestinal Cancer. 53(4), 948-957. https://doi.org/10.1007/s12029-021-00703-0