Journal article

Publication year: 2021

Pages: 1021-1034

Journal: Biomarkers in Medicine

Volume number: 15

Issue number: 12

ISSN: 1752-0363

eISSN: 1752-0371

DOI Link: https://doi.org/10.2217/bmm-2021-0009

Publisher: Taylor and Francis

Abstract: 
Aim: This study assessed the utility of osteopontin (OPN) and galectin-3 (Gal-3) as biomarkers of maladaptive right ventricular remodeling in pulmonary hypertension (PH). Materials & methods: We examined plasma levels of OPN and Gal-3 in patients with PH (n = 62), dilated cardiomyopathy (n = 34), left ventricular hypertrophy (LVH; n = 47), and controls without right ventricle (RV) or LV abnormalities (n = 38). Results: OPN and Gal-3 levels were higher in PH, dilated cardiomyopathy and LVH than in the controls. OPN concentrations in PH patients with maladaptive RV were significantly higher than in those with adaptive RV. Gal-3 did not differentiate between adaptive and maladaptive RV remodeling in PH. OPN and Gal-3 levels did not correlate with parameters of LV remodeling. Conclusion: OPN is a potential biomarker of RV maladaptation.

Harvard Citation style: Keranov, S., Doerr, O., Jafari, L., Liebetrau, C., Keller, T., Troidl, C., et al. (2021) Osteopontin and galectin-3 as biomarkers of maladaptive right ventricular remodeling in pulmonary hypertension, Biomarkers in Medicine, 15(12), pp. 1021-1034. https://doi.org/10.2217/bmm-2021-0009

APA Citation style: Keranov, S., Doerr, O., Jafari, L., Liebetrau, C., Keller, T., Troidl, C., Riehm, J., Rutsatz, W., Bauer, P., Kriechbaum, S., Voss, S., Richter, M., Tello, K., Gall, H., Ghofrani, H., Guth, S., Seeger, W., Hamm, C., & Nef, H. (2021). Osteopontin and galectin-3 as biomarkers of maladaptive right ventricular remodeling in pulmonary hypertension. Biomarkers in Medicine. 15(12), 1021-1034. https://doi.org/10.2217/bmm-2021-0009