Journal article
Authors list: Aksan, Ayseguel; Farrag, Karima; Blumenstein, Irina; Schroeder, Oliver; Dignass, Axel U.; Stein, Juergen
Publication year: 2021
Pages: 3440-3465
Journal: World Journal of Gastroenterology
Volume number: 27
Issue number: 24
ISSN: 1007-9327
eISSN: 2219-2840
Open access status: Hybrid
DOI Link: https://doi.org/10.3748/wjg.v27.i24.3440
Publisher: Baishideng Publishing Group
Abstract:
Chronic intestinal failure (CIF) is a rare but feared complication of Crohn's disease. Depending on the remaining length of the small intestine, the affected intestinal segment, and the residual bowel function, CIF can result in a wide spectrum of symptoms, from single micronutrient malabsorption to complete intestinal failure. Management of CIF has improved significantly in recent years. Advances in home-based parenteral nutrition, in particular, have translated into increased survival and improved quality of life. Nevertheless, 60% of patients are permanently reliant on parenteral nutrition. Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy. The outcomes of patients with CIF could be greatly improved by more effective prevention, understanding, and treatment. In complex cases, the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation, nutritional support, and an improved quality of life. Here, we summarize current literature on CIF and short bowel syndrome, encompassing epidemiology, pathophysiology, and advances in surgical and medical management, and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease.
Citation Styles
Harvard Citation style: Aksan, A., Farrag, K., Blumenstein, I., Schroeder, O., Dignass, A. and Stein, J. (2021) Chronic intestinal failure and short bowel syndrome in Crohn's disease, World Journal of Gastroenterology, 27(24), pp. 3440-3465. https://doi.org/10.3748/wjg.v27.i24.3440
APA Citation style: Aksan, A., Farrag, K., Blumenstein, I., Schroeder, O., Dignass, A., & Stein, J. (2021). Chronic intestinal failure and short bowel syndrome in Crohn's disease. World Journal of Gastroenterology. 27(24), 3440-3465. https://doi.org/10.3748/wjg.v27.i24.3440
Keywords
ACID REPLACEMENT THERAPY; BACTERIAL OVERGROWTH; BONE-MINERAL DENSITY; Chronic intestinal failure; Crohn's disease; DOSE GROWTH-HORMONE; DOUBLE-BLIND; HOME PARENTERAL-NUTRITION; Inflammatory bowel disease; INFRARED REFLECTANCE ANALYSIS; Intestinal failure-associated liver disease; INTRAABDOMINAL SEPTIC COMPLICATIONS; IRON-DEFICIENCY ANEMIA; Parenteral nutrition; Short bowel syndrome
