Journal article

Publication year: 2021

Pages: 2109-2121

Journal: Nutrition, Metabolism & Cardiovascular Diseases

Volume number: 31

Issue number: 7

ISSN: 0939-4753

eISSN: 1590-3729

DOI Link: https://doi.org/10.1016/j.numecd.2021.03.024

Publisher: Elsevier

Abstract: 
Background and aims: Early life exposures could be pertinent risk factors of cardiometabolic diseases in adulthood. We assessed the prospective associations of early life factors with markers of cardiometabolic risk among healthy German adults. Methods and results: We examined 348 term-born DONALD Study participants with measurement of fasting blood at the age of 18-24 years to assess metabolic indices: fatty liver index (FLI), hepatic steatosis index (HSI), pro-inflammatory score and insulin sensitivity (HOMA2-%S). Early life factors (maternal weight in early pregnancy, maternal early pregnancy BMI, gestational weight gain (GWG), maternal age, birth weight and full breastfeeding (>17 weeks)) were assessed at enrolment of the offspring into the study. Multivariable linear regression models were used to analyze associations between early life factors and markers of cardiometabolic risk in early adulthood with adjustment for potential confounders. A higher early pregnancy BMI was related to notably higher levels of offspring FLI, HSI, proinflammatory score and a lower HOMA2-%S (all p < 0.0001). Similarly, a higher gestational weight gain was associated with a higher FLI (p = 0.044), HSI (p = 0.016), pro-inflammatory score (p = 0.032) and a lower HOMA2-%S among females (p = 0.034). Full breastfeeding was associated with a lower adult FLI (p = 0.037). A casual mediation analysis showed that these associations were mediated by offspring adult waist circumference (WC). Conclusion: This study suggests that early pregnancy BMI, gestational weight gain, and full breastfeeding are relevant for offspring markers of cardiometabolic risk which seems to be mediated by body composition in young adulthood. (c)& nbsp;2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Harvard Citation style: Nyasordzi, J., Conrad, J., Goletzke, J., Ludwig-Walz, H., Herder, C., Roden, M., et al. (2021) Early life factors and their relevance for markers of cardiometabolic risk in early adulthood, Nutrition, Metabolism & Cardiovascular Diseases, 31(7), pp. 2109-2121. https://doi.org/10.1016/j.numecd.2021.03.024

APA Citation style: Nyasordzi, J., Conrad, J., Goletzke, J., Ludwig-Walz, H., Herder, C., Roden, M., Wudy, S., Hua, Y., Remer, T., & Buyken, A. (2021). Early life factors and their relevance for markers of cardiometabolic risk in early adulthood. Nutrition, Metabolism & Cardiovascular Diseases. 31(7), 2109-2121. https://doi.org/10.1016/j.numecd.2021.03.024