Journal article

Publication year: 2021

Pages: 447-457

Journal: Journal of Membrane Biology

Volume number: 254

Issue number: 5-6

ISSN: 0022-2631

eISSN: 1432-1424

Open access status: Hybrid

DOI Link: https://doi.org/10.1007/s00232-021-00184-z

Publisher: Springer

Abstract: 
The Na,K-ATPase establishes the electrochemical gradient of cells by driving an active exchange of Na+ and K+ ions while consuming ATP. The minimal functional transporter consists of a catalytic alpha-subunit and a beta-subunit with chaperon activity. The Na,K-ATPase also functions as a cell adhesion molecule and participates in various intracellular signaling pathways. The maturation and trafficking of the Na,K-ATPase include co- and post-translational processing of the enzyme in the endoplasmic reticulum (ER) and the Golgi apparatus and subsequent delivery to the plasma membrane (PM). The ER folding of the enzyme is considered as the rate-limiting step in the membrane delivery of the protein. It has been demonstrated that only assembled Na,K-ATPase alpha:beta-complexes may exit the organelle, whereas unassembled, misfolded or unfolded subunits are retained in the ER and are subsequently degraded. Loss of function of the Na,K-ATPase has been associated with lung, heart, kidney and neurological disorders. Recently, it has been shown that ER dysfunction, in particular, alterations in the homeostasis of the organelle, as well as impaired ER-resident chaperone activity may impede folding of Na,K-ATPase subunits, thus decreasing the abundance and function of the enzyme at the PM. Here, we summarize our current understanding on maturation and subsequent processing of the Na,K-ATPase in the ER under physiological and pathophysiological conditions.

Harvard Citation style: Kryvenko, V., Vagin, O., Dada, L., Sznajder, J. and Vadasz, I. (2021) Maturation of the Na,K-ATPase in the Endoplasmic Reticulum in Health and Disease, Journal of Membrane Biology, 254(5-6), pp. 447-457. https://doi.org/10.1007/s00232-021-00184-z

APA Citation style: Kryvenko, V., Vagin, O., Dada, L., Sznajder, J., & Vadasz, I. (2021). Maturation of the Na,K-ATPase in the Endoplasmic Reticulum in Health and Disease. Journal of Membrane Biology. 254(5-6), 447-457. https://doi.org/10.1007/s00232-021-00184-z