Journal article

Publication year: 2021

Pages: 404-410

Journal: Heart Rhythm

Volume number: 18

Issue number: 3

ISSN: 1547-5271

eISSN: 1556-3871

Open access status: Hybrid

DOI Link: https://doi.org/10.1016/j.hrthm.2020.11.025

Publisher: Elsevier

Abstract: 

BACKGROUND Data on the arrhythmic burden of women at risk for sudden cardiac death are limited, especially in patients using the wearable cardioverter-defibrillator (WCD).

OBJECTIVE We aimed to characterize WCD compliance, atrial and ventricular arrhythmic burden, and WCD outcomes by sex in patients enrolled in the Prospective Registry of Patients Using the Wearable Cardioverter Defibrillator (WEARIT-II U.S. Registry).

METHODS In the WEARIT-II Registry, we stratified 2000 patients by sex into women (n = 598) and men (n = 1402). WCD wear time, ventricular and atrial arrhythmic events during WCD use, and implantable cardioverter-defibrillator (ICD) implantation rates at the end of WCD use were evaluated.

RESULTS The mean WCD wear time was similar in women and men (94 days vs 90 days; P = .145), with longer daily use in women (21.4 h/d vs 20.7 h/d; P = .001). Burden of ventricular tachycardia or ventricular fibrillation was higher in women, with 30 events per 100 patient-years compared with 18 events per 100 patient-years in men (P = .017), with similar findings for treated and non-treated ventricular tachycardia/ventricular fibrillation. Recurrent atrial arrhythmias/sustained ventricular tachycardia was also more frequent in women than in men (167 events per 100 patient-years vs 73 events per 100 patient-years; P = .042). However, ICD implantation rate at the end of WCD use was similar in both women and men (41% vs 39%; P = .448).

CONCLUSION In the WEARIT-II Registry, we have shown a higher burden of ventricular and atrial arrhythmic events in women than in men. ICD implantation rates at the end of WCD use were similar. Our findings warrant monitoring women at risk for sudden cardiac death who have a high burden of atrial and ventricular arrhythmias while using the WCD.

Harvard Citation style: Goldenberg, I., Erath, J., Russo, A., Burch, A., Assmus, B., Bonderman, D., et al. (2021) Sex differences in arrhythmic burden with the wearable cardioverter-defibrillator, Heart Rhythm, 18(3), pp. 404-410. https://doi.org/10.1016/j.hrthm.2020.11.025

APA Citation style: Goldenberg, I., Erath, J., Russo, A., Burch, A., Assmus, B., Bonderman, D., McNitt, S., & Kutyifa, V. (2021). Sex differences in arrhythmic burden with the wearable cardioverter-defibrillator. Heart Rhythm. 18(3), 404-410. https://doi.org/10.1016/j.hrthm.2020.11.025