Journalartikel

Jahr der Veröffentlichung: 2021

Seiten: 172-182

Zeitschrift: Pathologe

Bandnummer: 42

Heftnummer: 2

ISSN: 0172-8113

eISSN: 1432-1963

Open Access Status: Hybrid

DOI Link: https://doi.org/10.1007/s00292-021-00924-x

Verlag: Springer

Abstract: 
The health effects of coronavirus disease 2019 (COVID-19) caused by the infection of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) are becoming increasingly clear as the pandemic spreads. In addition to the lungs, other organs are also affected, which can significantly influence morbidity and mortality. In particular, neurological symptoms involving the central nervous system can lead to acute or long-term consequences. The mechanisms of this neuropathogenesis of SARS-CoV-2 infection and its relation to acute and chronic neurological symptoms are the subject of current studies investigating a potential direct and indirect viral infection of the nervous system. The following review summarizes the current status of neuropathological manifestations, molecular pathogenesis, possible infection pathways in the nervous system, and systemic effects. In addition, an overview of the Germany-wide CNS-COVID19 registry and collaborations is presented, which should contribute to a better understanding of the neurological symptoms of COVID-19.

Harvard-Zitierstil: Ritschel, N., Radbruch, H., Herden, C., Schneider, N., Dittmayer, C., Franz, J., et al. (2021) COVID-19 and the central and peripheral nervous system, Pathologe, 42(2), pp. 172-182. https://doi.org/10.1007/s00292-021-00924-x

APA-Zitierstil: Ritschel, N., Radbruch, H., Herden, C., Schneider, N., Dittmayer, C., Franz, J., Thomas, C., Silva Boos, G., Pagenstecher, A., Schulz-Schaeffer, W., Stadelmann, C., Glatzel, M., Heppner, F., Weis, J., Sohrabi, K., Schanzer, A., Nemeth, A., & Acker, T. (2021). COVID-19 and the central and peripheral nervous system. Pathologe. 42(2), 172-182. https://doi.org/10.1007/s00292-021-00924-x