Journal article

Publication year: 2021

Journal: PLoS ONE

Volume number: 16

Issue number: 1

ISSN: 1932-6203

Open access status: Gold

DOI Link: https://doi.org/10.1371/journal.pone.0245768

Publisher: Public Library of Science

Abstract: 
We investigate the power densities which are obtainable locally in a vibration bioreactor. These reactor systems are of great relevance for research about oncological or antibacterial therapies. Our focus lies on the local liquid pressure caused by resonance vibration in the fluid contained by the reactor's petri dish. We use for the excitation one piezoelectric patch which offer advantages concerning controllability and reproducibility, when compared to ultrasound. The experimental work is extended by finite element analyses of bioreactor details. The peaks of the vibration response for water, sodium chloride (0.1N Standard solution), and McCoy's 5A culture medium are in good alignment. Several natural frequencies can be observed. Local power density can reach multiple times the magnitude used in ultrasound studies. Based on the observed local power densities, we are planning future work for the exposure of cell cultures to mechanical vibration.

Harvard Citation style: Valentin, D., Presas, A., Roehr, C., Mele, E., Biehl, C., Heiss, C., et al. (2021) On the quantification of local power densities in a new vibration bioreactor, PLoS ONE, 16(1), Article e0245768. https://doi.org/10.1371/journal.pone.0245768

APA Citation style: Valentin, D., Presas, A., Roehr, C., Mele, E., Biehl, C., Heiss, C., & Bosbach, W. (2021). On the quantification of local power densities in a new vibration bioreactor. PLoS ONE. 16(1), Article e0245768. https://doi.org/10.1371/journal.pone.0245768