Journal article

Publication year: 2021

Pages: 3423-3432

Journal: World Journal of Urology

Volume number: 39

Issue number: 9

ISSN: 0724-4983

eISSN: 1433-8726

Open access status: Hybrid

DOI Link: https://doi.org/10.1007/s00345-021-03614-8

Publisher: Springer

Abstract: 
Purpose To evaluate and report the complications, and to analyse antimicrobial stewardship aspects following prostate biopsies (P-Bx) based on the data from a 9-year global study. Methods The primary outcome was to compare complications after P-Bx between patients of two cohorts: 2010-2014 and 2016-2019. Primary outcomes included symptoms of lower and severe/systemic urinary tract infection (LUTIS and SUTIS, respectively), and positive urine culture. Readmission to hospital after P-Bx, need for additional antimicrobial therapy, consumption of different antimicrobial agents for prophylaxis and therapy were evaluated. Students t test and chi-square test were used for comparative analyses. Results Outcome data were available for 1615 men. Fluoroquinolones-based prophylaxis rate increased from 72.0% in 2010-2014 to 78.6% in 2015-2019. Overall rates of complications increased from 6 to 11.7% including an increase in symptomatic complications from 4.7 to 10.2%, mainly due to an increase in LUTIS. Rates of patients seeking additional medical help in primary care after P-Bx increased from 7.4 to 14.4%; cases requiring post P-Bx antibiotic treatment increased from 6.1 to 9.7%, most of which received fluoroquinolones. Transperineal P-Bx was significantly associated with LUTIS. Following transrectal P-Bx, 2.8% developed febrile infections and 4.0% required hospitalisation. Two men (0.12%) died after transrectal P-Bx due to sepsis. Conclusions The rates of complications after P-Bx tended to increase in time, as well as rates of patients seeking additional medical help in the post-P-Bx period. To reduce the risk of infectious complications and to comply with the principles of antibiotic stewardship, clinicians should switch to the transperineal biopsy route.

Harvard Citation style: Alidjanov, J., Cai, T., Bartoletti, R., Bonkat, G., Bruyere, F., Koves, B., et al. (2021) The negative aftermath of prostate biopsy: prophylaxis, complications and antimicrobial stewardship: results of the global prevalence study of infections in urology 2010-2019, World Journal of Urology, 39(9), pp. 3423-3432. https://doi.org/10.1007/s00345-021-03614-8

APA Citation style: Alidjanov, J., Cai, T., Bartoletti, R., Bonkat, G., Bruyere, F., Koves, B., Kulchavenya, E., Medina-Polo, J., Naber, K., Perepanova, T., Pilatz, A., Tandogdu, Z., Bjerklund Johansen, T., & Wagenlehner, F. (2021). The negative aftermath of prostate biopsy: prophylaxis, complications and antimicrobial stewardship: results of the global prevalence study of infections in urology 2010-2019. World Journal of Urology. 39(9), 3423-3432. https://doi.org/10.1007/s00345-021-03614-8