Journal article

Publication year: 2021

Pages: 826-831

Journal: The Journal of Urology

Volume number: 205

Issue number: 3

ISSN: 0022-5347

eISSN: 1527-3792

Open access status: Hybrid

DOI Link: https://doi.org/10.1097/JU.0000000000001425

Publisher: Lippincott, Williams & Wilkins

Abstract: 

Purpose: Extraintestinal pathogenic Escherichia coli (ExPEC) are a leading cause of invasive infections in adults. The study aimed to evaluate the incidence of microbiologically confirmed invasive ExPEC disease in patients undergoing transrectal ultrasound-guided prostate needle biopsy (TRUS-PNB), O-serotype distribution and antibiotic resistance profiles of associated E. coli isolates.

Materials and Methods: Adult men (>= 18 years) undergoing TRUS-PNB were enrolled. The TRUS- PNB procedure was performed according to local standard of care, including preferences of prophylactic antibiotics. Clinical and microbiological data were collected.

Results: Of the 4,951 patients (mean age 66.9 years) enrolled 4,935 (99.7%) underwent TRUS-PNB (95.1% received prophylactic antibiotics); 98.9% completed the study. Overall incidence of invasive ExPEC disease was 0.67% (33/4,935 patients; 95% CI 0.46-0.94); highest incidence was in the U.S. (0.97%, 14/1,446; 95% CI 0.53-1.62). Prevalence of the 10 selected O-serotypes O1, O2, O4, O6, O8, O15, O16, O18, O25 and O75 was 52.0% (95% CI 31.3-72.2). E. coli isolates showed highest resistance rates to levofloxacin and ciprofloxacin (76%; 95% CI 54.8-90.6 for both). Among fluoroquinolone-resistant ExPEC isolates, prevalence of the 10 selected O-serotypes was 60%.

Conclusions: This study provides an estimate of microbiologically confirmed invasive ExPEC disease incidence following TRUS- PNB. Information on E. coli O-serotype distribution and associated antibiotic resistance profiles from invasive ExPEC disease cases in the first 30 days following TRUS-PNB may help guiding antibiotic use and inform development of a prophylactic ExPEC vaccine.

Harvard Citation style: Rosenberg, S., Bonten, M., Haazen, W., Spiessens, B., Abbanat, D., Go, O., et al. (2021) Epidemiology and O-Serotypes of Extraintestinal Pathogenic Escherichia coli Disease in Patients Undergoing Transrectal Ultrasound Prostate Biopsy: A Prospective Multicenter Study, The Journal of Urology, 205(3), pp. 826-831. https://doi.org/10.1097/JU.0000000000001425

APA Citation style: Rosenberg, S., Bonten, M., Haazen, W., Spiessens, B., Abbanat, D., Go, O., Wagenlehner, F., Shore, N., Hagiwara, Y., de Palacios, P., Geurtsen, J., Hermans, P., & Poolman, J. (2021). Epidemiology and O-Serotypes of Extraintestinal Pathogenic Escherichia coli Disease in Patients Undergoing Transrectal Ultrasound Prostate Biopsy: A Prospective Multicenter Study. The Journal of Urology. 205(3), 826-831. https://doi.org/10.1097/JU.0000000000001425