Journal article
Authors list: Lakpour, Niknam; Saliminejad, Kioomars; Ghods, Roya; Sadeghi, Mohammad Reza; Pilatz, Adrian; Khosravi, Farhad; Madjd, Zahra
Publication year: 2021
Journal: Andrologia
Volume number: 53
Issue number: 4
ISSN: 0303-4569
eISSN: 1439-0272
Open access status: Gold
DOI Link: https://doi.org/10.1111/and.13998
Publisher: Wiley
Abstract:
Testicular germ cell tumour (TGCT) is considered a relatively rare malignancy usually occurring in young men between 15 and 35 years of age, and both genetic and environmental factors contribute to its development. The majority of patients are diagnosed in an early-stage of TGCTs with an elevated 5-year survival rate after therapy. However, approximately 25% of patients show an incomplete response to chemotherapy or tumours relapse. The current therapies are accompanied by several adverse effects, including infertility. Aside from classical serum biomarker, many studies reported novel biomarkers for TGCTs, but without proper validation. Cancer cells share many similarities with embryonic stem cells (ESCs), and since ESC genes are not transcribed in most adult tissues, they could be considered ideal candidate targets for cancer-specific diagnosis and treatment. Added to this, several microRNAs (miRNA) including miRNA-371-3p can be further investigated as a molecular biomarker for diagnosis and monitoring of TGCTs. In this review, we will illustrate the findings of recent investigations in novel TGCTs biomarkers applicable for risk assessment, screening, diagnosis, prognosis, prediction and monitoring of the relapse.
Citation Styles
Harvard Citation style: Lakpour, N., Saliminejad, K., Ghods, R., Sadeghi, M., Pilatz, A., Khosravi, F., et al. (2021) Potential biomarkers for testicular germ cell tumour: Risk assessment, diagnostic, prognostic and monitoring of recurrence, Andrologia, 53(4), Article e13998. https://doi.org/10.1111/and.13998
APA Citation style: Lakpour, N., Saliminejad, K., Ghods, R., Sadeghi, M., Pilatz, A., Khosravi, F., & Madjd, Z. (2021). Potential biomarkers for testicular germ cell tumour: Risk assessment, diagnostic, prognostic and monitoring of recurrence. Andrologia. 53(4), Article e13998. https://doi.org/10.1111/and.13998
Keywords
AURORA-B EXPRESSION; CANCER-PATIENTS; C-KIT PROTEIN; CLINICAL-RELEVANCE; GENOME-WIDE ASSOCIATION; GROWTH-FACTOR RECEPTOR; MICRORNA MIR-371A-3P; nonseminoma; PLACENTAL ALKALINE-PHOSPHATASE; Seminoma; SERUM-LEVELS; Testicular cancer
