Journal article

Publication year: 2020

Journal: Journal of Personalized Medicine

Volume number: 10

Issue number: 4

eISSN: 2075-4426

Open access status: Gold

DOI Link: https://doi.org/10.3390/jpm10040251

Publisher: MDPI

Abstract: 
Studies assessing the long-term outcome after heart transplantation HTX in patients with cardiomyopathy (CM) in the paediatric age range are rare. The aim of this study was to determine the survival rate of children with CM undergoing HTX and to analyse how aetiology of cardiomyopathy influenced morbidity and mortality. We retrospectively analysed the medical records of children; who were transplanted in our centre between June 1988 and October 2019. 236 heart transplantations were performed since 1988 (9 re-transplants). 98 of 227 patients (43.2%) were transplanted because of CM. Survival rates were 93% after 1; 84% after 10 and 75% after 30 years. Overall; the aetiology of CM could be clearly identified in 37 subjects (37.7%). This rate increased up to 66.6% (12/19) by applying a comprehensive diagnostic workup since 2016. The survival rate was lower (p < 0.05) and neurocognitive deficits were more frequent (p = 0.001) in subjects with systemic diseases than in individuals with cardiac-specific conditions. These data indicate that the long-term survival rate of children with CM after HTX in experienced centers is high. A comprehensive diagnostic workup allows unraveling the basic defect in the majority of patients with CM undergoing HTX. Aetiology of CM affects morbidity and mortality in subjects necessitating HTX.

Harvard Citation style: Zschirnt, M., Thul, J., Akintuerk, H., Valeske, K., Schranz, D., Skrzypek, S., et al. (2020) Aetiology and 30-Year Long-Term Outcome of Children with Cardiomyopathy Necessitating Heart Transplantation, Journal of Personalized Medicine, 10(4), Article 251. https://doi.org/10.3390/jpm10040251

APA Citation style: Zschirnt, M., Thul, J., Akintuerk, H., Valeske, K., Schranz, D., Skrzypek, S., Muller, M., Jux, C., Hahn, A., & Rupp, S. (2020). Aetiology and 30-Year Long-Term Outcome of Children with Cardiomyopathy Necessitating Heart Transplantation. Journal of Personalized Medicine. 10(4), Article 251. https://doi.org/10.3390/jpm10040251