Journalartikel
Autorenliste: Ubags, Niki D. J.; Alcazar, Miguel A. Alejandre; Kallapur, Suhas G.; Knapp, Sylvia; Lanone, Sophie; Lloyd, Clare M.; Morty, Rory E.; Pattaroni, Celine; Reynaert, Niki L.; Rottier, Robbert J.; Smits, Hermelijn H.; Piters, Wouter A. A. de Steenhuijsen; Strickland, Deborah H.; Collins, Jennifer J. P.
Jahr der Veröffentlichung: 2020
Zeitschrift: European Respiratory Review
Bandnummer: 29
Heftnummer: 157
ISSN: 0905-9180
eISSN: 1600-0617
Open Access Status: Gold
DOI Link: https://doi.org/10.1183/16000617.0191-2020
Verlag: European Respiratory Society
Abstract:
The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune system and consequent initiation and progression of respiratory diseases is still emerging. Recent studies investigating the developmental origins of lung diseases have started to delineate the effects of early-life changes in the lung, environmental exposures and immune maturation on the development of childhood and adult lung diseases. While the influencing factors have been described and studied in mostly animal models, it remains challenging to pinpoint exactly which factors and at which time point are detrimental in lung development leading to respiratory disease later in life. To advance our understanding of early origins of chronic lung disease and to allow for proper dissemination and application of this knowledge, we propose four major focus areas: 1) policy and education; 2) clinical assessment; 3) basic and translational research; and 4) infrastructure and tools, and discuss future directions for advancement. This review is a follow-up of the discussions at the European Respiratory Society Research Seminar "Early origins of lung disease: towards an interdisciplinary approach" (Lisbon, Portugal, November 2019).
Zitierstile
Harvard-Zitierstil: Ubags, N., Alcazar, M., Kallapur, S., Knapp, S., Lanone, S., Lloyd, C., et al. (2020) Early origins of lung disease: towards an interdisciplinary approach, European Respiratory Review, 29(157), Article 200191. https://doi.org/10.1183/16000617.0191-2020
APA-Zitierstil: Ubags, N., Alcazar, M., Kallapur, S., Knapp, S., Lanone, S., Lloyd, C., Morty, R., Pattaroni, C., Reynaert, N., Rottier, R., Smits, H., Piters, W., Strickland, D., & Collins, J. (2020). Early origins of lung disease: towards an interdisciplinary approach. European Respiratory Review. 29(157), Article 200191. https://doi.org/10.1183/16000617.0191-2020
Schlagwörter
ADULT MICE; A VIRUS-INFECTION; CYTOKINE PRODUCTION; EARLY-LIFE EXPOSURES; IMMUNE DEVELOPMENT; INCREASES SENSITIVITY; LONG-TERM PULMONARY; MESENCHYMAL STROMAL CELLS; NEONATAL HYPEROXIA
