Journal article

Publication year: 2020

Journal: Journal of Clinical Medicine

Volume number: 9

Issue number: 10

eISSN: 2077-0383

Open access status: Gold

DOI Link: https://doi.org/10.3390/jcm9103340

Publisher: MDPI

Abstract: 
During surgery, ATP from damaged cells induces the release of interleukin-1 beta, a potent pro-inflammatory cytokine that contributes to the development of postoperative systemic inflammation, sepsis and multi-organ damage. We recently demonstrated that C-reactive protein (CRP) inhibits the ATP-induced release of monocytic interleukin-1 beta, although high CRP levels are deemed to be a poor prognostic marker. Here, we retrospectively investigated if preoperative CRP levels correlate with postoperative CRP, leukocyte counts and fever in the context of anatomical lung resection and systematic lymph node dissection as first line lung cancer therapy. No correlation was found in the overall results. In men, however, preoperative CRP and leukocyte counts positively correlated on postoperative days one to two, and a negative correlation of CRP and fever was seen in women. These correlations were more pronounced in men taking statins and in statin-naive women. Accordingly, the inhibitory effect of CRP on the ATP-induced interleukin-1 beta release was blunted in monocytes from coronary heart disease patients treated with atorvastatin compared to monocytes obtained before medication. Hence, the common notion that elevated CRP levels predict more severe postoperative inflammation should be questioned. We rather hypothesize that in women and statin-naive patients, high CRP levels attenuate trauma-induced increases in inflammatory markers.

Harvard Citation style: Meyer, M., Brandenburg, L., Hudel, H., Agne, A., Padberg, W., Erdogan, A., et al. (2020) Who Is Afraid of CRP? Elevated Preoperative CRP Levels Might Attenuate the Increase in Inflammatory Parameters in Response to Lung Cancer Surgery, Journal of Clinical Medicine, 9(10), Article 3340. https://doi.org/10.3390/jcm9103340

APA Citation style: Meyer, M., Brandenburg, L., Hudel, H., Agne, A., Padberg, W., Erdogan, A., Nef, H., Amati, A., Dorr, O., Witte, B., & Grau, V. (2020). Who Is Afraid of CRP? Elevated Preoperative CRP Levels Might Attenuate the Increase in Inflammatory Parameters in Response to Lung Cancer Surgery. Journal of Clinical Medicine. 9(10), Article 3340. https://doi.org/10.3390/jcm9103340