Journalartikel

Jahr der Veröffentlichung: 2020

Seiten: 694-705

Zeitschrift: Journal of Allergy and Clinical Immunology

Bandnummer: 146

Heftnummer: 4

ISSN: 0091-6749

eISSN: 1097-6825

Open Access Status: Hybrid

DOI Link: https://doi.org/10.1016/j.jaci.2020.07.027

Verlag: Elsevier

Abstract: 
The nuclear factor kappa B (NF-kappa B) signaling system, a key regulator of immunologic processes, also affects a plethora of metabolic changes associated with inflammation and the immune response. NF-kappa B-regulating signaling cascades, in concert with NF-kappa B-mediated transcriptional events, control the metabolism at several levels. NF-kappa B modulates apical components of metabolic processes including metabolic hormones such as insulin and glucagon, the cellular master switches 5' AMP-activated protein kinase and mTOR, and also numerous metabolic enzymes and their respective regulators. Vice versa, metabolic enzymes and their products also exert multilevel control of NF-kappa B activity, thereby creating a highly connected regulatory network. These insights have resulted in the identification of the noncanonical I kappa B kinase kinases I kappa B kinase 3 and TBK1, which are upregulated by overnutrition, and may therefore be suitable potential therapeutic targets for metabolic syndromes. An inhibitor interfering with the activity of both kinases reduces obesity-related metabolic dysfunctions in mouse models and the encouraging results from a recent clinical trial indicate that targeting these NF-kappa B pathway components improves glucose homeostasis in a subset of patients with type 2 diabetes.

Harvard-Zitierstil: Kracht, M., Mueller-Ladner, U. and Schmitz, M. (2020) Mutual regulation of metabolic processes and proinflammatory NF-κB signaling, Journal of Allergy and Clinical Immunology, 146(4), pp. 694-705. https://doi.org/10.1016/j.jaci.2020.07.027

APA-Zitierstil: Kracht, M., Mueller-Ladner, U., & Schmitz, M. (2020). Mutual regulation of metabolic processes and proinflammatory NF-κB signaling. Journal of Allergy and Clinical Immunology. 146(4), 694-705. https://doi.org/10.1016/j.jaci.2020.07.027